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Dipeptidyl Peptidase 4 Is a Novel Adipokine Potentially Linking Obesity to the Metabolic Syndrome
DPP4 is a novel adipokine that may impair insulin sensitivity in an autocrine and paracrine fashion and release strongly correlates with adipocyte size, potentially representing an important source of DPP4 in obesity. Expand
Adaptive immunity in obesity and insulin resistance
The evidence for infiltration of adipose tissue by cells of the adaptive immune system, how adaptive system cells affect innate cell populations and the influence of adaptive immune cells on the development of insulin resistance are summarized. Expand
Evidence against a Beneficial Effect of Irisin in Humans
It is rather unlikely that the beneficial effect of irisin observed in mice can be translated to humans, according to analyses of genomic DNA, mRNA and expressed sequence tags. Expand
DPP4 in Diabetes
Dipeptidyl-peptidase 4 (DPP4) is a glycoprotein of 110 kDa, which is ubiquitously expressed on the surface of a variety of cells. This exopeptidase selectively cleaves N-terminal dipeptides from aExpand
The role of epicardial and perivascular adipose tissue in the pathophysiology of cardiovascular disease
Fat depots around the heart and vasculature; Alterations in obesity and insulin resistance; and Perspectives and conclusions. Expand
Pigment epithelium-derived factor (PEDF) is one of the most abundant proteins secreted by human adipocytes and induces insulin resistance and inflammatory signaling in muscle and fat cells
PEDF is one of the most abundant adipokines and its secretion is inversely regulated by insulin and hypoxia, which could have an important role in diabetes and obesity-related disorders. Expand
Adiponectin counteracts cytokine- and fatty acid-induced apoptosis in the pancreatic beta-cell line INS-1
The data show that gAcrp30 partially rescues beta cells from cytokine- and fatty acid-induced apoptosis and completely restores autoimmune- and lipotoxicity-induced dysfunction of insulin-producing cells. Expand
Identification and Validation of Novel Adipokines Released from Primary Human Adipocytes*
Validation experiments conducted for complement factor H, αB-crystallin, cartilage intermediate-layer protein, and heme oxygenase-1 show that the release and expression of these factors in adipocytes is regulated by differentiation and stimuli, which affect insulin sensitivity, as well as by obesity. Expand
Randomized comparison of reduced fat and reduced carbohydrate hypocaloric diets on intrahepatic fat in overweight and obese human subjects
The decrease in intrahepatic lipids appears to be independent of visceral fat loss and is not tightly coupled with changes in whole body insulin sensitivity during 6 months of an energy restricted diet. Expand
Inflammation and metabolic dysfunction: links to cardiovascular diseases.
The most prominent link to cardiovascular disease was found for leptin, TNF-α, adipocyte fatty acid-binding protein, interleukins, and several novel adipokines such as lipocalin-2 and pigment epithelium-derived factor. Expand