• Publications
  • Influence
The Physiology of Synapses
  • J. Eccles
  • Biology
    Springer Berlin Heidelberg
  • 1964
TLDR
This chapter discusses the development of ideas on the synapse, the ionic mechanism generating the inhibitory postsynaptic potential, and the trophic and plastic properties of synapses.
The excitatory synaptic action of climbing fibres on the Purkinje cells of the cerebellum
TLDR
Investigation of this synaptic mechanism in the cerebellum of the cat has been based on the discovery by Szentagothai & Rajkovits (1959) that the climbing fibres have their cells of origin in the contralateral inferior olive.
Pharmacological studies on presynaptic inhibition
TLDR
Physiological investigations on presynaptic inhibition have led to the hypothesis that it is effected by chemically transmitting synapses that impinge on the terminal knobs of excitatory synapses and exert a depolarizing action thereon.
Parallel fibre stimulation and the responses induced thereby in the Purkinje cells of the cerebellum
TLDR
Investigations by microelectrode recording established that this wave is produced by impulses propagating for at least 3 mm and at about 0.3 m/sec along a narrow superficial band or “beam” of parallel fibres, and there was an absolutely refractory period of less than 1 msec and impulse annihilation by collision.
Interactions between motoneurones and muscles in respect of the characteristic speeds of their responses
TLDR
An analytic investigation into the influence of nerve on muscle has been accomplished by dividing and cross-uniting nerves to fast and slow muscles, so that motoneurones formerly innervating the fast muscle come to innervate the slow muscle by virtue of the regenerative outgrowth of their fibres.
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