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Larvicidal diterpenes from Pterodon polygalaeflorus.
Ethanolic extract from seeds of Pterodon polygalaeflorus (Benth) has been shown to possess significant larvicidal activity against the mosquito Aedes aegypti. Bioassay-guided fractionation of theExpand
In vitro antiplasmodial activity of Brazilian Cerrado plants used as traditional remedies.
Twenty-seven species of native Brazilian Cerrado plants commonly used by traditional healers to treat malaria and other diseases were collected and 204 hexanic and ethanolic extracts obtained by maceration and showed significant inhibition rates of Plasmodium falciparum growth. Expand
The larvicidal properties of these species are described for the first time, and may prove to be promising in active chemical compound isolation. Expand
Cytotoxic activity of Brazilian Cerrado plants used in traditional medicine against cancer cell lines.
To investigate the cytotoxic potential of 412 extracts from Brazilian Cerrado plants used in traditional medicine belonging to 21 families against tumor cell lines in culture,Bioassay-guided fractionation of the last extract led to the isolation of glaucarubinone, which showed pronounced activity against the four cell lines studied. Expand
Larvicidal activity of Cybistax antisyphilitica against Aedes aegypti larvae.
The larvicidal activity against Aedes aegypti larvae of a stem wood hexane extract of Cybistax antisyphilitica was evaluated and a natural quinone identified as 2-hydroxy-3-(3-methyl-2-butenyl)-1.4-naphthoquinone (lapachol) was quite potent against A. aeEgypti larvae. Expand
Larvicidal activities against Aedes aegypti of some Brazilian medicinal plants.
Larvicidal activities against Aedes aegypti have been determined in the ethanolic extracts obtained from 51 Brazilian medicinal plants, and should be of value in the search for new natural larvicidal compounds. Expand
Trypanocidal activity of a new diterpene from Casearia sylvestris var. lingua.
Bioassay-guided fractionation of the hexanic root bark extract of Casearia sylvestris var. lingua led to the isolation of a new clerodane diterpene, whose structure was elucidated as rel-(2 S,5 R,6Expand
Down-modulation of nitric oxide production in murine macrophages treated with crude plant extracts from the Brazilian Cerrado.
The ethanolic stem bark and leaf extracts of Serjania lethalis and Cupania vernalis, respectively, almost completely inhibited the production of NO by J774 macrophages, indicating potential sources of active compounds that might be used as anti-inflammatory agents. Expand
Investigation of plant extracts in traditional medicine of the Brazilian Cerrado against protozoans and yeasts.
The active extracts for protozoans and human pathogenic yeasts are considered promising to continue the search for the identification and development of leading compounds. Expand
Evaluation of the antifungal potential of Brazilian Cerrado medicinal plants
Extracts of Cerrado plants are of particular interest as source of new agents for the treatment of dermatophytic infections, and their minimal inhibitory concentrations (MIC) were determined by microdilution method. Expand