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Functional properties of human muscle fibers after short-term resistance exercise training.
The aim of this study was to assess the relationships between human muscle fiber hypertrophy, protein isoform content, and maximal Ca(2+)-activated contractile function following a short-term periodExpand
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Differential Roles of Cardiac Myosin-Binding Protein C and Cardiac Troponin I in the Myofibrillar Force Responses to Protein Kinase A Phosphorylation
The heart is remarkably adaptable in its ability to vary its function to meet the changing demands of the circulatory system. During times of physiological stress, cardiac output increases inExpand
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Acceleration of Crossbridge Kinetics by Protein Kinase A Phosphorylation of Cardiac Myosin Binding Protein C Modulates Cardiac Function
Normal cardiac function requires dynamic modulation of contraction. β1-Adrenergic–induced protein kinase (PK)A phosphorylation of cardiac myosin binding protein (cMyBP)-C may regulate crossbridgeExpand
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Ablation of myosin-binding protein-C accelerates force development in mouse myocardium.
Myosin-binding protein-C (MyBP-C) is a thick filament-associated protein that binds tightly to myosin. Given that cMyBP-C may act to modulate cooperative activation of the thin filament byExpand
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Contributions of Stretch Activation to Length-dependent Contraction in Murine Myocardium
The steep relationship between systolic force production and end diastolic volume (Frank-Starling relationship) in myocardium is a potentially important mechanism by which the work capacity of theExpand
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Functional adaptability of muscle fibers to long-term resistance exercise.
PURPOSE We compared the functional properties of muscle fibers from two groups of subjects that differed widely in their training history to investigate whether long-term resistance exercise altersExpand
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Activation Dependence of Stretch Activation in Mouse Skinned Myocardium: Implications for Ventricular Function
Recent evidence suggests that ventricular ejection is partly powered by a delayed development of force, i.e., stretch activation, in regions of the ventricular wall due to stretch resulting fromExpand
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Acceleration of Stretch Activation in Murine Myocardium due to Phosphorylation of Myosin Regulatory Light Chain
The regulatory light chains (RLCs) of vertebrate muscle myosins bind to the neck region of the heavy chain domain and are thought to play important structural roles in force transmission between theExpand
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Determination of rate constants for turnover of myosin isoforms in rat myocardium: implications for in vivo contractile kinetics.
The ventricles of small mammals express mostly alpha-myosin heavy chain (alpha-MHC), a fast isoform, whereas the ventricles of large mammals, including humans, express approximately 10% alpha-MHC onExpand
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Effect of hindlimb suspension on the functional properties of slow and fast soleus fibers from three strains of mice.
Cross-sectional area (CSA), peak Ca2+-activated force (Po), fiber specific force (Po/CSA), and unloaded shortening velocity (Vo) were measured in slow-twitch [containing type I myosin heavy chainExpand
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