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Tetrahedron Letters
A new strategy for the synthesis of (+)-vernolepin (1), (+)-vernodalin (2), and (+)-8-deoxyvernolepin (3), from the accessible germacrolides (+)-salonitenolide (4) and (+)-costunolide (5), has beenExpand
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
From a marine-derived strain of the fungus Emericella variecolor, varitriol (1), varioxirane (2), dihydroterrein (3), and varixanthone (4), besides the known mold metabolites ergosterol, terrein,Expand
Gibepyrones: α-pyrones from Gibberella fujikuroi
Abstract Six α-pyrones, called gibepyrones A-F, were identified in three different culture media of G. fujikuroi (IMI 58289). Their structures were determined using both spectroscopic techniques andExpand
New sources and antifungal activity of sesquiterpene lactones.
Results suggest that a relatively low polarity is one of the molecular requirements for the antifungal activity of sesquiterpene lactones. Expand
Stereochemistry of 14-hydroxy-β-caryophyllene and related compounds
The isomerization of β-caryophyllene (3), under treatment with SeO2, is described. Chemical correlations, between 3 14--hydroxy-β-caryophylllene (6z) from Juniperus oxycedrus, are establised. HighExpand
Water: the ideal hydrogen-atom source in free-radical chemistry mediated by Ti(III) and other single-electron-transfer metals?
Solid evidence is shown to show that water really can act as a complete hydrogen-atom source rather than as a simple proton donor for radical reductions mediated by Ti and, presumably, other metals that react by single-electron transfer. Expand
Effects of solvents and water in Ti(III)-mediated radical cyclizations of epoxygermacrolides. Straightforward synthesis and absolute stereochemistry of (+)-3alpha-hydroxyreynosin and related
The results obtained suggest that the combination of the biomimetic strategy employed, with Ti(III)-mediated free-radical chemistry, may come to represent a general method for the enantiospecific synthesis of more than 170 natural eudesmanolides containing an exocyclic double bond between C-4 and C-15. Expand
Phycomysterols and other sterols from the fungus Phycomyces blakesleeanus.
In the search for novel bioactive products from filamentous fungi, sterols and triterpenoids found in Phycomyces blakesleeanus were analyzed using semipreparative HPLC, GC-MS, and NMR techniques and structures proposed for the three new compounds identified were confirmed by chemical synthesis. Expand
Lactones from species from Centaurea. Cytotoxic and antimicrobial activities
Some germacranolides and the new natural product (+)-tulipalin B were isolated from four species of the Centaurea genus and the cytotoxic and antimicrobial activities of the natural lactones and their derivatives were screened. Expand
Sterols in erg mutants of Phycomyces: metabolic pathways and physiological effects
All analyzed mutants synthesized ergosta-7,22,24(28)-trien-3beta-ol, demonstrating for the first time that the sterol C-22 dehydrogenase of Phycomyces is capable of recognizing sterols with a 24(28) unsaturated side chain. Expand