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Studies on the Mechanism of Action of Topical Benzoyl Peroxide and Vitamin A Acid in Acne Vulgaris
- J. E. Fulton, A. Farzad-Bakshandeh, S. Bradley
- Medicine, BiologyJournal of cutaneous pathology
- 1 October 1974
The effective agent, benzoyl peroxide, produced a mild desquamation: while concommitantly reducing the fatty acids in sebum more dramatically than systemic tetracycline.
Comedogenicity of current therapeutic products, cosmetics, and ingredients in the rabbit ear.
Comedogenicity and irritancy of commonly used ingredients in skin care products
- J. E. Fulton
By following the guidelines developed in this study, it is possible to formulate nonirritating, noncomedogenic moisturizers, sunscreens, hair pomades, cosmetics, and conditioners.
Inhibition of lipid synthesis by clofibrate: comparative study of human skin, rat skin, and rat liver in vitro.
Of the three tissues studied, human skin was the most sensitive to the drug and yielded more reproducible results, and the inhibitory effect of clofibrate was also demonstrated.
The glycerol ester hydrolase (EC 220.127.116.11) from Corynebacterium acnes: a serine lipase.
Lipid Synthesis from Acetate-1-14C by Suction Blister Epidermis and Other Skin Components 1
- S. Hsia, J. E. Fulton, D. Fulghum, M. Buch
- Biology, Environmental ScienceProceedings of the Society for Experimental…
- 1 November 1970
The epidermis excised from suction blisters was found active in synthesizing lipids from acetate-l-14C, and the activity appeared to increase after the ingestion of 100 g of glucose, indicating metabolic regulation of lipid synthesis in the epidermi.
The choice of vitamin A acid, erythromycin, or benzoyl peroxide for the topical treatment of acne.
The use of this formulation in susceptible acne-prone women reduced the rate of "acne cosmetica" in clinic patients from 25% to less than 5% and was unable to confirm a recent study suggesting that sulfur was a potent acnegen.