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Novel Mechanism of Activation of NADPH Oxidase 5
In contrast to other Nox isoforms, the activity of Nox5 does not require the presence of accessory proteins and is entirely dependent on the elevation of intracellular calcium. Previous studies haveExpand
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Functional Relevance of Golgi- and Plasma Membrane–Localized Endothelial NO Synthase in Reconstituted Endothelial Cells
Objective—We have previously shown in COS-7 cells that targeting of endothelial NO synthase (eNOS) to the Golgi or plasma membrane (PM) regulates the mechanism and degree of eNOS activation. However,Expand
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Differences in eNOS Activity Because of Subcellular Localization Are Dictated by Phosphorylation State Rather than the Local Calcium Environment*
Nitric oxide (NO) produced in the endothelium via the enzyme endothelial nitric-oxide synthase (eNOS) is an important vasoactive compound. Wild-type (WT) eNOS is localized to the plasma membrane andExpand
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Src Kinase Activates Endothelial Nitric-oxide Synthase by Phosphorylating Tyr-83*
The endothelial nitric-oxide synthase (eNOS) is regulated in part by serine/threonine phosphorylation, but eNOS tyrosine phosphorylation is less well understood. In the present study we have examinedExpand
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Role of local production of endothelium-derived nitric oxide on cGMP signaling and S-nitrosylation.
Nitric oxide (NO), synthesized by endothelial nitric oxide synthase (eNOS), exerts control over vascular function via two distinct mechanisms, the activation of soluble guanylate cyclaseExpand
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Inhibition of endothelial nitric oxide synthase by the lipid phosphatase PTEN.
PTEN (phosphatase and tensin homologue deleted on chromosome 10) is a lipid phosphatase that functions as a negative regulator of the phosphoinositide-3-kinase (PI3K) pathway. The present studyExpand
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Stonefish (Synanceia trachynis) Antivenom: In Vitro Efficacy and Clinical Use
Certain species of fish have long been recognised as venomous. Although venomous fish do not represent a substantial source of human mortality, they are responsible for a number of envenomations eachExpand
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Selective coupling of type 6 adenylyl cyclase with type 2 IP3receptors mediates direct sensitization of IP3receptors by cAMP
Tovey et al. 2008. J. Cell Biol. doi:10.1083/jcb.200803172 [OpenUrl][1][Abstract/FREE Full Text][2] [1]:Expand
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Proceedings of the Australian Physiological Society Symposium: Signals Mediating Exercise-Induced Skeletal Muscle Remodelling Novel role for b-adrenergic signalling in skeletal muscle growth,
1. In adult mammals, skeletal muscle mass is maintained through a precise balance of protein synthesis and protein degradation, whereas during development cellular (not protein) turnoverExpand
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