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A Plant-Like Kinase in Plasmodium falciparum Regulates Parasite Egress from Erythrocytes
It's a Knockout The malaria parasite is one of the most important pathogens of humans. Increasing drug-resistance is an imminent public health disaster, and we urgently need to find new drugs. TheExpand
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HIV-1 infection requires a functional integrase NLS.
HIV-1 is able to infect nondividing cells productively in part because the postentry viral nucleoprotein complexes are actively imported into the nucleus. In this manuscript, we identify a novelExpand
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A DOC2 Protein Identified by Mutational Profiling Is Essential for Apicomplexan Parasite Exocytosis
Parasite Invasion Strategy Exocytosis is essential to the lytic cycle of apicomplexan parasites and is required for the pathogenesis of toxoplasmosis and malaria. DOC2 proteins recruit the membraneExpand
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Reassessment of the Roles of Integrase and the Central DNA Flap in Human Immunodeficiency Virus Type 1 Nuclear Import
ABSTRACT Human immunodeficiency virus type 1 (HIV-1) can infect nondividing cells productively because the nuclear import of viral nucleic acids occurs in the absence of cell division. A number ofExpand
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Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors.
Plasmodium falciparum NDH2 (pfNDH2) is a non-proton pumping, rotenone-insensitive alternative enzyme to the multi-subunit NADH:ubiquinone oxidoreductases (Complex I) of many other eukaryotes.Expand
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Identification and Characterization of Small Molecule Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase*
Plasmodium falciparum causes the most deadly form of malaria and accounts for over one million deaths annually. The malaria parasite is unable to salvage pyrimidines and relies on de novoExpand
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Antibodies to PfSEA-1 block parasite egress from RBCs and protect against malaria infection
Novel vaccines are urgently needed to reduce the burden of severe malaria. Using a differential whole-proteome screening method, we identified Plasmodium falciparum schizont egress antigen-1Expand
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Suggestive Evidence for Darwinian Selection against Asparagine-Linked Glycans of Plasmodium falciparum and Toxoplasma gondii
ABSTRACT We are interested in asparagine-linked glycans (N-glycans) of Plasmodium falciparum and Toxoplasma gondii, because their N-glycan structures have been controversial and because weExpand
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Calcium-Dependent Protein Kinase 5 Is Required for Release of Egress-Specific Organelles in Plasmodium falciparum
ABSTRACT The human malaria parasite Plasmodium falciparum requires efficient egress out of an infected red blood cell for pathogenesis. This egress event is highly coordinated and is mediated byExpand
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PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum
Calcium Dependent Protein Kinases are key effectors of calcium signaling in malaria parasite. PfCDPK1 is critical for asexual development of Plasmodium falciparum, but its precise function andExpand
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