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Long-term effect of continuous positive airway pressure in hypertensive patients with sleep apnea.
TLDR
In nonsleepy hypertensive patients with OSA, CPAP treatment for 1 year is associated with a small decrease in BP, and this effect is evident only in patients who use CPAP for more than 5.6 hours per night.
Effect of CPAP on blood pressure in patients with obstructive sleep apnea and resistant hypertension: the HIPARCO randomized clinical trial.
TLDR
Among patients with OSA and resistant hypertension, CPAP treatment for 12 weeks compared with control resulted in a decrease in 24-hour mean and diastolic blood pressure and an improvement in the nocturnal blood pressure pattern.
Severe Sleep Apnea and Risk of Ischemic Stroke in the Elderly
TLDR
Severe obstructive sleep apnea hypopnea (defined as apnea-hypopnea index ≥30) increases the risk of ischemic stroke in the elderly population, independent of known confounding factors.
Cardiovascular mortality in obstructive sleep apnea in the elderly: role of long-term continuous positive airway pressure treatment: a prospective observational study.
TLDR
Severe OSA not treated with CPAP is associated with cardiovascular death in the elderly, and adequate CPAP treatment may reduce this risk.
The influence of obesity and obstructive sleep apnea on metabolic hormones
TLDR
It is found that sleep apnea was not a determinant factor in leptin, adiponectin, and ghrelin hormonal levels, and nCPAP treatment diminishes leptin in obese OSA patients and adip onectin levels in obese and non-obese patients with OSAS.
Continuous positive airway pressure treatment reduces mortality in patients with ischemic stroke and obstructive sleep apnea: a 5-year follow-up study.
TLDR
It is suggested that long-term CPAP treatment in moderate to severe OSA and ischemic stroke is associated with a reduction in excess risk of mortality.
Neuropeptide Y and leptin in patients with obstructive sleep apnea syndrome: role of obesity.
TLDR
It is concluded that NPY and leptin plasma levels are increased in patients with OSAS, whereas the former appear independent of obesity, the latter are mostly associated with obesity.
Effect of continuous positive airway pressure on the incidence of hypertension and cardiovascular events in nonsleepy patients with obstructive sleep apnea: a randomized controlled trial.
TLDR
In patients with OSA without daytime sleepiness, the prescription of CPAP compared with usual care did not result in a statistically significant reduction in the incidence of hypertension or cardiovascular events, and the study may have had limited power to detect a significant difference.
Association between obstructive sleep apnea and cancer incidence in a large multicenter Spanish cohort.
TLDR
Increased overnight hypoxia as a surrogate of OSA severity was associated with increased cancer incidence, and this association seems to be limited to men and patients younger than 65 years of age.
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