• Publications
  • Influence
Molecular Bases for Circadian Clocks
  • J. Dunlap
  • Biology, Medicine
  • Cell
  • 22 January 1999
been PERFRQT, reflecting the Drosophila period gene Dartmouth Medical School and the Neurospora frequency gene (the fruits of the Hanover, New Hampshire 03755 first decades of genetic and molecularExpand
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A high-throughput gene knockout procedure for Neurospora reveals functions for multiple transcription factors
The low rate of homologous recombination exhibited by wild-type strains of filamentous fungi has hindered development of high-throughput gene knockout procedures for this group of organisms. In thisExpand
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The genome sequence of the filamentous fungus Neurospora crassa
Neurospora crassa is a central organism in the history of twentieth-century genetics, biochemistry and molecular biology. Here, we report a high-quality draft sequence of the N. crassa genome. TheExpand
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Lessons from the Genome Sequence of Neurospora crassa: Tracing the Path from Genomic Blueprint to Multicellular Organism
SUMMARY We present an analysis of over 1,100 of the ∼10,000 predicted proteins encoded by the genome sequence of the filamentous fungus Neurospora crassa. Seven major areas of Neurospora genomics andExpand
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The PAS Protein VIVID Defines a Clock-Associated Feedback Loop that Represses Light Input, Modulates Gating, and Regulates Clock Resetting
vvd, a gene regulating light responses in Neurospora, encodes a novel member of the PAS/LOV protein superfamily. VVD defines a circadian clock-associated autoregulatory feedback loop that influencesExpand
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Neurospora wc-1 and wc-2: transcription, photoresponses, and the origins of circadian rhythmicity.
Circadian rhythmicity is universally associated with the ability to perceive light, and the oscillators ("clocks") giving rise to these rhythms, which are feedback loops based on transcription andExpand
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Light-Induced Resetting of a Mammalian Circadian Clock Is Associated with Rapid Induction of the mPer1Transcript
To understand how light might entrain a mammalian circadian clock, we examined the effects of light on mPer1, a sequence homolog of Drosophila per, that exhibits robust rhythmic expression in theExpand
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White Collar-1, a Circadian Blue Light Photoreceptor, Binding to the frequency Promoter
In the fungus Neurospora crassa, the blue light photoreceptor(s) and signaling pathway(s) have not been identified. We examined light signaling by exploiting the light sensitivity of the NeurosporaExpand
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Genome‐wide analysis of light‐inducible responses reveals hierarchical light signalling in Neurospora
White collar‐1 (WC‐1) and white collar‐2 (WC‐2) are essential for light‐mediated responses in Neurospora crassa, but the molecular mechanisms underlying gene induction and the roles of other real andExpand
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Interconnected feedback loops in the Neurospora circadian system.
In Neurospora crassa, white collar 1 (WC-1), a transcriptional activator and positive clock element, is rhythmically expressed from a nonrhythmic steady-state pool of wc-1 transcript, consistent withExpand
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