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Acetylcholine‐induced relaxation in blood vessels from endothelial nitric oxide synthase knockout mice
TLDR
It is demonstrated that in the blood vessels studied, the endothelium‐dependent relaxations to acetylcholine involve either NO or the combination of NO plus a product of cyclo‐oxygenase but not EDHF; in the eNOS(−/−) mice, NO‐dependent responses and EDHF‐like responses were not observed. Expand
Acute and chronic administration of melanin-concentrating hormone enhances food intake and body weight in Wistar and Sprague–Dawley rats
TLDR
The results strongly suggest that MCH is an orexigenic peptide involved in the control of both short- and long term food intake in satiated rats and further indicate that the MCH pathway is a possible target for theControl of food intake and obesity. Expand
Cannabinoid CB1 receptor and endothelium‐dependent hyperpolarization in guinea‐pig carotid, rat mesenteric and porcine coronary arteries
TLDR
Whether or not the endothelium‐dependent hyperpolarizations of the vascular smooth muscle cells (observed in the presence of inhibitors of nitric oxide synthase and cyclo‐oxygenase) can be attributed to the production of an endogenous cannabinoid is investigated. Expand
Role of endothelial cell hyperpolarization in EDHF‐mediated responses in the guinea‐pig carotid artery
TLDR
Results indicate that in the vascular smooth muscle cells of the guinea‐pig carotid artery, a conductance specifically sensitive to the combination of charybdotoxin plus apamin could not be detected, comforting the hypothesis that the combined force of these two toxins should act on the endothelial cells. Expand
Potassium ions and endothelium‐derived hyperpolarizing factor in guinea‐pig carotid and porcine coronary arteries
TLDR
Results indicate that, in two different vascular preparations, barium sensitive‐inwardly rectifying potassium conductance and the ouabain sensitive‐Na+/K+ pump are not involved in the EDHF‐mediated hyperpolarization. Expand
Epoxyeicosatrienoic acids, potassium channel blockers and endothelium‐dependent hyperpolarization in the guinea‐pig carotid artery
TLDR
The results indicate that, in the guinea‐pig internal carotid artery, the involvement of metabolites of arachidonic acid through the cytochrome P450 pathway in endothelium‐dependent hyperpolarization is unlikely and is probably not due to the opening of BKCa channels. Expand
Glucose and insulin modulate the capacity of endothelial cells (HUVEC) to express P-selectin and bind a monocytic cell line (U937).
TLDR
It is shown that high glucose concentration activates endothelial cells leading to monocytes adhesion providing further evidence that hyperglycaemia might be implicated in vessel wall lesions contributing to diabetic vascular disease. Expand
K+ Channels in Cultured Bovine Retinal Pericytes: Effects of &bgr;‐Adrenergic Stimulation
TLDR
Bovine retinal pericytes express mainly two outward potassium currents, KV and BKCa, as well as an inward rectifying K+ current, Kir, suggesting a potential role for these channels in the control of retinal blood flow. Expand
Food intake regulation in rodents: Y5 or Y1 NPY receptors or both?
TLDR
Results do not allow one to conclude on the implication of a single receptor subtype at the molecular level, but this approach is crucial for the design of novel NPY receptor antagonists with potential use as anti-obesity drugs and for evaluation of their possible adverse peripheral side effects, such as hypotension. Expand
Reduced food intake in response to CGP 71683A may be due to mechanisms other than NPY Y5 receptor blockade
TLDR
It is concluded that CGP 71683A is an imprecise tool for investigating the role of the NPY Y5 receptor in the control of physiological processes including food intake and an inflammatory response associated with the fall in food intake is demonstrated. Expand
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