• Publications
  • Influence
Dicer1 and miR-219 Are Required for Normal Oligodendrocyte Differentiation and Myelination
To investigate the role of microRNAs in regulating oligodendrocyte (OL) differentiation and myelination, we utilized transgenic mice in which microRNA processing was disrupted in OL precursor cellsExpand
  • 408
  • 48
Myelin Gene Regulatory Factor Is a Critical Transcriptional Regulator Required for CNS Myelination
The transcriptional control of CNS myelin gene expression is poorly understood. Here we identify gene model 98, which we have named myelin gene regulatory factor (MRF), as a transcriptional regulatorExpand
  • 310
  • 33
Functional Genomic Analysis of Oligodendrocyte Differentiation
To better understand the molecular mechanisms governing oligodendrocyte (OL) differentiation, we have used gene profiling to quantitatively analyze gene expression in synchronously differentiatingExpand
  • 265
  • 25
CNS myelin wrapping is driven by actin disassembly.
Myelin is essential in vertebrates for the rapid propagation of action potentials, but the molecular mechanisms driving its formation remain largely unknown. Here we show that the initial stage ofExpand
  • 146
  • 19
Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain
Oligodendrocytes—the myelin-forming cells of the central nervous system—can be regenerated during adulthood. In adults, new oligodendrocytes originate from oligodendrocyte progenitor cells (OPCs),Expand
  • 106
  • 12
The T3-induced gene KLF9 regulates oligodendrocyte differentiation and myelin regeneration
Hypothyroidism is a well-described cause of hypomyelination. In addition, thyroid hormone (T3) has recently been shown to enhance remyelination in various animal models of CNS demyelination. What areExpand
  • 81
  • 8
Nur7 Is a Nonsense Mutation in the Mouse Aspartoacylase Gene That Causes Spongy Degeneration of the CNS
Aspartoacylase (ASPA) is an oligodendrocyte-restricted enzyme that catalyzes the hydrolysis of neuronally derived N-acetylaspartate (NAA) to acetate and aspartic acid. ASPA deficiency leads to theExpand
  • 54
  • 8
Disease Gene Candidates Revealed by Expression Profiling of Retinal Ganglion Cell Development
To what extent do postmitotic neurons regulate gene expression during development or after injury? We took advantage of our ability to highly purify retinal ganglion cells (RGCs) to profile theirExpand
  • 66
  • 7
Identification of a Gene Regulatory Network Necessary for the Initiation of Oligodendrocyte Differentiation
Differentiation of oligodendrocyte progenitor cells (OPCs) into mature oligodendrocytes requires extensive changes in gene expression, which are partly mediated by post-translational modifications ofExpand
  • 79
  • 6
MicroRNAs in Oligodendrocyte and Schwann Cell Differentiation
MicroRNAs (miRNAs) are a class of small (approx. 22 nt) noncoding RNAs that are capable of post-transcriptionally silencing mRNAs that contain sequences complementary to the miRNAs’ 7- to 8-bp ‘seed’Expand
  • 49
  • 6