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Perioperative management of antithrombotic therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
BACKGROUND This guideline addresses the management of patients who are receiving anticoagulant or antiplatelet therapy and require an elective surgery or procedure. METHODS The methods herein… Expand
Systematic overview of warfarin and its drug and food interactions.
BACKGROUND Warfarin is a highly efficacious oral anticoagulant, but its use is limited by a well-founded fear of bleeding. Drug and food interactions are frequently cited as causes of adverse events… Expand
2006 Canadian clinical practice guidelines on the management and prevention of obesity in adults and children [summary]
- D. Lau, J. Douketis, K. Morrison, I. Hramiak, A. Sharma, E. Ur
- Canadian Medical Association Journal
- 10 April 2007
Obesity is now reaching epidemic proportions in both developed and developing countries and is affecting not only adults but also children and adolescents. Over the last 20 years, obesity has become… Expand
A comparison of two intensities of warfarin for the prevention of recurrent thrombosis in patients with the antiphospholipid antibody syndrome.
- M. Crowther, J. Ginsberg, +16 authors M. Kovacs
- The New England journal of medicine
- 18 September 2003
BACKGROUND Many patients with the antiphospholipid antibody syndrome and recurrent thrombosis receive doses of warfarin adjusted to achieve an international normalized ratio (INR) of more than 3.0.… Expand
Canadian guidelines for body weight classification in adults: application in clinical practice to screen for overweight and obesity and to assess disease risk
- J. Douketis, G. Paradis, H. Keller, C. Martineau
- Canadian Medical Association Journal
- 12 April 2005
Since 1985, the number of obese adults in Canada has doubled. According to 2003 data from Statistics Canada ([www.statcan.ca/english/freepub/82-221-XIE/00604/tables/html/1228_03.htm]), 15%… Expand
The perioperative management of antithrombotic therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).
This article discusses the perioperative management of antithrombotic therapy and is part of the American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). The… Expand
How I treat anticoagulated patients undergoing an elective procedure or surgery.
The periprocedural management of patients receiving long-term oral anticoagulant therapy remains a common but difficult clinical problem, with a lack of high-quality evidence to inform best… Expand
Systematic review of long-term weight loss studies in obese adults: clinical significance and applicability to clinical practice
- J. Douketis, C. Macie, L. Thabane, D. Williamson
- International Journal of Obesity
- 1 October 2005
BACKGROUND:Obesity is a common health problem that requires a long-term care approach. We systematically reviewed long-term (≥2 y) studies investigating dietary/lifestyle, pharmacologic, and surgical… Expand
Myocardial Injury after Noncardiac Surgery: A Large, International, Prospective Cohort Study Establishing Diagnostic Criteria, Characteristics, Predictors, and 30-day Outcomes
Background:Myocardial injury after noncardiac surgery (MINS) was defined as prognostically relevant myocardial injury due to ischemia that occurs during or within 30 days after noncardiac surgery.… Expand
Extended-duration prophylaxis against venous thromboembolism after total hip or knee replacement: a meta-analysis of the randomised trials
BACKGROUND The optimum duration of prophylaxis against venous thromboembolism after total hip or knee replacement is uncertain. Our primary objective was to establish the efficacy of… Expand