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The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat.
Dependence of subthalamic nucleus oscillations on movement and dopamine in Parkinson's disease.
- R. Levy, P. Ashby, W. Hutchison, A. Lang, A. Lozano, J. Dostrovsky
- BiologyBrain : a journal of neurology
- 1 June 2002
It is suggested that the firing of STN neurones can be synchronized by 15-30 Hz cortical beta oscillatory activity, particularly when dopamine deficiency results in a higher background firing rate of STn neurones, and that this synchronization contributes to parkinsonian pathophysiology.
Beta oscillatory activity in the subthalamic nucleus and its relation to dopaminergic response in Parkinson's disease.
The findings suggest that the degree of neuronal beta oscillatory activity is related to the magnitude of the response of the basal ganglia to dopaminergic agents rather than directly to the motor symptoms of PD.
High-frequency Synchronization of Neuronal Activity in the Subthalamic Nucleus of Parkinsonian Patients with Limb Tremor
This study examines the discharge activity of 121 pairs of subthalamic nucleus (STN) neurons in nine PD patients undergoing functional stereotactic mapping to demonstrate that in PD patients with limb tremor, many STN neurons display high-frequency oscillations with a high degree of in-phase synchrony.
Microstimulation-induced inhibition of neuronal firing in human globus pallidus.
- J. Dostrovsky, R. Levy, J. P. Wu, W. Hutchison, R. Tasker, A. Lozano
- Biology, MedicineJournal of neurophysiology
- 1 July 2000
It is suggested that microstimulation within GPi preferentially excites the axon terminals of striatal and/or external pallidal neurons causing release of GABA and inhibition of GPi neurons.
Pain-related neurons in the human cingulate cortex
- W. Hutchison, K. Davis, A. Lozano, R. Tasker, J. Dostrovsky
- Biology, PsychologyNature Neuroscience
- 1 May 1999
This work has identified single neurons in ACC that respond selectively to painful thermal and mechanical stimuli, supporting a role for the ACC in pain perception.
Unilateral pedunculopontine stimulation improves falls in Parkinson's disease.
It is suggested that pedunculopontine nucleus deep-brain stimulation may be effective in preventing falls in patients with advanced Parkinson's disease but that further evaluation of this procedure is required.
Synchronized Neuronal Discharge in the Basal Ganglia of Parkinsonian Patients Is Limited to Oscillatory Activity
The findings indicate that oscillatory synchronization between pairs of GPi or GPe neurons is found in patients with limb tremor and suggest that overt neuronal synchronization, which may be attributable to an increase in direct synaptic connections or common collateral afferent inputs, is not present in the basal ganglia of patients with PD.
Neurophysiological identification of the subthalamic nucleus in surgery for Parkinson's disease
These findings suggest that STN neuronal activity is elevated in Parkinson's disease, and electrical microstimulation of STN could produce tremor arrest but were and found to be useful for localization.
Effects of apomorphine on subthalamic nucleus and globus pallidus internus neurons in patients with Parkinson's disease.
- R. Levy, J. Dostrovsky, A. Lang, E. Sime, W. Hutchison, A. Lozano
- BiologyJournal of neurophysiology
- 1 July 2001
The findings suggest that the APO-induced amelioration of parkinsonian symptoms is not solely due to a decrease in overall activity in the GPi or STN as predicted by the current model of basal ganglia function in PD.