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The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat.
Rats with hippocampal damage are reported to be hyperactive in novel environments, 'perseverative' and resistant to extinction on tasks that they have learned, heedless of drastic changes in theirExpand
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Dependence of subthalamic nucleus oscillations on movement and dopamine in Parkinson's disease.
Local field potentials and pairs of neurones in the subthalamic nucleus (STN) of patients with Parkinson's disease show high-frequency oscillations (HFOs) at 15-30 Hz. This study explores how theseExpand
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Beta oscillatory activity in the subthalamic nucleus and its relation to dopaminergic response in Parkinson's disease.
Recent studies suggest that beta (15-30 Hz) oscillatory activity in the subthalamic nucleus (STN) is dramatically increased in Parkinson's disease (PD) and may interfere with movement execution.Expand
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High-frequency Synchronization of Neuronal Activity in the Subthalamic Nucleus of Parkinsonian Patients with Limb Tremor
It has been hypothesized that in Parkinson's disease (PD) there is increased synchronization of neuronal firing in the basal ganglia. This study examines the discharge activity of 121 pairs ofExpand
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Microstimulation-induced inhibition of neuronal firing in human globus pallidus.
Neurosurgical treatment of Parkinson's disease (PD) frequently employs chronic high-frequency deep brain stimulation (DBS) within the internal segment of globus pallidus (GPi) and can veryExpand
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Unilateral pedunculopontine stimulation improves falls in Parkinson's disease.
Postural instability and falls are a major source of disability in patients with advanced Parkinson's disease. These problems are currently not well addressed by either pharmacotherapy nor byExpand
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Pain-related neurons in the human cingulate cortex
Although it is widely accepted that the cortex participates in pain perception, there is no direct evidence for the existence of cortical neurons that respond to noxious or painful stimuli in humans.Expand
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Synchronized Neuronal Discharge in the Basal Ganglia of Parkinsonian Patients Is Limited to Oscillatory Activity
It has been proposed that an increase in synchronization between neurons in the basal ganglia contributes to the clinical features of Parkinson's disease (PD). To examine this hypothesis, we lookedExpand
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Neurophysiological identification of the subthalamic nucleus in surgery for Parkinson's disease
Microelectrode recording methods for stereotactic localization of the subthalamic nucleus (STN) and surrounding structures are described. These methods accurately define targets for chronic deepExpand
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Effects of apomorphine on subthalamic nucleus and globus pallidus internus neurons in patients with Parkinson's disease.
This study examines the effect of apomorphine (APO), a nonselective D(1)- and D(2)-dopamine receptor agonist, on the firing activity of neurons in the subthalamic nucleus (STN) and internal segmentExpand
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