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A Roadmap for Natural Product Discovery Based on Large-Scale Genomics and Metabolomics
Actinobacteria encode a wealth of natural product biosynthetic gene clusters (NPGCs), whose systematic study is complicated by numerous repetitive motifs. By combining several metrics we developed aExpand
Taxonomic evaluation of Streptomyces albus and related species using multilocus sequence analysis and proposals to emend the description of Streptomyces albus and describe Streptomyces pathocidini
In phylogenetic analyses of the genus Streptomyces using 16S rRNA gene sequences, Streptomyces albus subsp. albus NRRL B-1811(T) forms a cluster with five other species having identical or nearlyExpand
Widespread homologous recombination within and between Streptomyces species
Horizontal gene transfer (HGT) is widespread in the microbial world, but its impact on the origin and persistence of microbial species remains poorly defined. HGT can result in either acquisition ofExpand
Comparative genomics of actinomycetes with a focus on natural product biosynthetic genes
BackgroundActinomycetes are a diverse group of medically, industrially and ecologically important bacteria, studied as much for the diseases they cause as for the cures they hold. The genomes ofExpand
Phylogenetic relationships in the family Streptomycetaceae using multi-locus sequence analysis
The family Streptomycetaceae, notably species in the genus Streptomyces, have long been the subject of investigation due to their well-known ability to produce secondary metabolites. The emergence ofExpand
Curcumin inhibits herpes simplex virus immediate-early gene expression by a mechanism independent of p300/CBP histone acetyltransferase activity.
Curcumin, a phenolic compound from the curry spice turmeric, exhibits a wide range of activities in eukaryotic cells, including antiviral effects that are at present incompletely characterized.Expand
Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes
Significance The discovery of natural products, an important source of human medicines, is critical for the development of new therapeutics against health threats, including cancer andExpand
Diversity and abundance of phosphonate biosynthetic genes in nature
Significance Phosphonic acids are organophosphorus molecules containing direct carbon–phosphorus bonds that are often perceived as biological rarities. The data presented here show that the abilityExpand
The genomic landscape of ribosomal peptides containing thiazole and oxazole heterocycles
BackgroundRibosomally synthesized and post-translationally modified peptides (RiPPs) are a burgeoning class of natural products with diverse activity that share a similar origin and common featuresExpand
Strain-specific proteogenomics accelerates the discovery of natural products via their biosynthetic pathways
The use of proteomics for direct detection of expressed pathways producing natural products has yielded many new compounds, even when used in a screening mode without a bacterial genome sequenceExpand