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A human gut microbial gene catalogue established by metagenomic sequencing
TLDR
The Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals are described, indicating that the entire cohort harbours between 1,000 and 1,150 prevalent bacterial species and each individual at least 160 such species. Expand
Enterotypes of the human gut microbiome
TLDR
Three robust clusters (referred to as enterotypes hereafter) are identified that are not nation or continent specific and confirmed in two published, larger cohorts, indicating that intestinal microbiota variation is generally stratified, not continuous. Expand
Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
TLDR
The results suggest that counterbalancing dysbiosis using F. prausnitzii as a probiotic is a promising strategy in CD treatment and exhibits anti-inflammatory effects on cellular and TNBS colitis models, partly due to secreted metabolites able to block NF-κB activation and IL-8 production. Expand
Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach
TLDR
The metagenomic approach allowed us to detect a reduced complexity of the bacterial phylum Firmicutes as a signature of the faecal microbiota in patients with CD, and indicated the presence of new bacterial species. Expand
Enterotypes of the human gut microbiome
This corrects the article DOI: 10.1038/nature09944
An integrated catalog of reference genes in the human gut microbiome
TLDR
The integrated gene catalog (IGC) is established comprising 9,879,896 genes, which includes close-to-complete sets of genes for most gut microbes, which are also of considerably higher quality than in previous catalogs. Expand
Richness of human gut microbiome correlates with metabolic markers
TLDR
The authors' classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities. Expand
Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota
TLDR
A unified signature of gut microbiome shifts in T2D with a depletion of butyrate-producing taxa is reported, highlighting the need to disentangle gut microbiota signatures of specific human diseases from those of medication. Expand
Towards the human intestinal microbiota phylogenetic core.
TLDR
Despite the species richness and a high individual specificity, a limited number of OTUs is shared among individuals and might represent the phylogenetic core of the human intestinal microbiota and its role in human health deserves further study. Expand
The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age
TLDR
It is demonstrated that the fecal microbiota composition evolves throughout life, from early childhood to old age, and that the ratio of Firmicutes to Bacteroidetes evolves during different life stages. Expand
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