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Neuroendocrine Tumors of the Lung With Proposed Criteria for Large‐Cell Neuroendocrine Carcinoma: An Ultrastructural, Immunohistochemical, and Flow Cytometric Study of 35 Cases
TLDR
Although the prognosis of LCNEC appears to be intermediate between AC and SCLC, larger numbers of patients will be needed to demonstrate significant differences in survival, and any advantage to IHC, EM, or flow cytometry over light microscopy in the subclassification or prediction of prognosis is not found.
Petrosal sinus sampling with and without corticotropin-releasing hormone for the differential diagnosis of Cushing's syndrome.
TLDR
Simultaneous bilateral sampling of plasma from the inferior petrosal sinuses, with the adjunctive use of CRH, distinguishes patients with Cushing's disease from those with ectopic adrenocorticotropin secretion with high diagnostic accuracy.
Spinal arteriovenous malformations: a comparison of dural arteriovenous fistulas and intradural AVM's in 81 patients.
TLDR
It is suggested that dural and intradural AVM's differ in etiology (acquired vs. congenital) and that they have different pathophysiology, radiographic findings, clinical presentation, and response to treatment.
Cushing's syndrome in children and adolescents. Presentation, diagnosis, and therapy.
TLDR
Weight gain and growth retardation are common clinical characteristics of Cushing's syndrome in children and adolescents and diagnostic evaluation of such patients with CRH stimulation alone and combined with inferior petrosal sinus sampling and imaging studies is accurate, and therapy is usually successful.
Germline mutations of the MEN1 gene in familial multiple endocrine neoplasia type 1 and related states.
TLDR
Familial multiple endocrine neoplasia type 1 (FMEN1) is an autosomal dominant trait characterized by tumors of the parathyroids, gastro-intestinal endocrine tissue, anterior pituitary and other tissues, supporting the prediction that MEN1 is a tumor suppressing gene.
Pituitary Magnetic Resonance Imaging in Normal Human Volunteers: Occult Adenomas in the General Population
TLDR
Magnetic resonance imaging (MRI) at 1.5 tesla, combined with the use of the paramagnetic contrast agent, gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA), enhances the capacity to visualize the pituitary gland and to screen patients forpituitary adenomas and evaluated the pituitsary gland before and after administration of Gd- DTPA in 100 volunteers.
Hemiparkinsonism in monkeys after unilateral internal carotid artery infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
TLDR
This animal hemiparkinsonian model will be useful in studies of volitional movement control, drug treatments of Parkinson's disease, and functional efficacy of brain tissue implants.
Zollinger‐Ellison Syndrome: Clinical Presentation in 261 Patients
TLDR
The initial presenting symptoms in 261 patients with Zollinger-Ellison syndrome (ZES) over a 25-year period were evaluated, finding that abdominal pain and diarrhea were the most common symptoms, present in 75% and 73% of patients, respectively.
Symptomatic vertebral hemangiomas: treatment by means of direct intralesional injection of ethanol.
TLDR
Direct injection of ethanol into symptomatic vertebral hemangioma is an effective and safe treatment, provided the dose is less than 15 mL.
Insulinomas: localization with selective intraarterial injection of calcium.
TLDR
The authors believe noninvasive ASVS may replace invasive portal venous sampling as the most effective method for the localization of occult insulinomas.
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