Neuronal ensemble control of prosthetic devices by a human with tetraplegia
- L. Hochberg, M. Serruya, J. Donoghue
- Biology, MedicineNature
- 1 July 2006
Initial results for a tetraplegic human using a pilot NMP suggest that NMPs based upon intracortical neuronal ensemble spiking activity could provide a valuable new neurotechnology to restore independence for humans with paralysis.
A point process framework for relating neural spiking activity to spiking history, neural ensemble, and extrinsic covariate effects.
- W. Truccolo, U. Eden, M. Fellows, J. Donoghue, E. Brown
- Computer Science, BiologyJournal of Neurophysiology
- 1 February 2005
A statistical framework based on the point process likelihood function to relate a neuron's spiking probability to three typical covariates: the neuron's own spiking history, concurrent ensemble activity, and extrinsic covariates such as stimuli or behavior.
Reach and grasp by people with tetraplegia using a neurally controlled robotic arm
- L. Hochberg, D. Bacher, J. Donoghue
- Medicine, PsychologyNature
- 10 April 2012
The results demonstrate the feasibility for people with tetraplegia, years after injury to the central nervous system, to recreate useful multidimensional control of complex devices directly from a small sample of neural signals.
Plasticity and primary motor cortex.
- J. Sanes, J. Donoghue
- Biology, PsychologyAnnual Review of Neuroscience
- 2000
The intrinsic horizontal neuronal connections in MI are a strong candidate substrate for map reorganization: They interconnect large regions of MI, they show activity-dependent plasticity, and they modify in association with skill learning.
The motor cortex of the rat: Cytoarchitecture and microstimulation mapping
- J. Donoghue, S. Wise
- BiologyThe Journal of comparative neurology
- 20 November 1982
The first motor cortex of the rat was identified as the region from which movements could be evoked by the lowest intensity of electrical stimulation and was correlated with Cytoarchitecture in the frontal and parietal cortex.
Bayesian Population Decoding of Motor Cortical Activity Using a Kalman Filter
- Wei Wu, Yun Gao, E. Bienenstock, J. Donoghue, Michael J. Black
- Computer Science, BiologyNeural Computation
- 2006
A real-time system that uses Bayesian inference techniques to estimate hand motion from the firing rates of multiple neurons, which provides a principled probabilistic model of motor-cortical coding, decodes hand motion in real time, provides an estimate of uncertainty, and is straightforward to implement.
Neural control of computer cursor velocity by decoding motor cortical spiking activity in humans with tetraplegia
- Sung-Phil Kim, J. Simeral, L. Hochberg, J. Donoghue, Michael J. Black
- BiologyJournal of Neural Engineering
- 17 November 2008
In two tetraplegic participants, it was found that controlling a cursor's velocity resulted in more accurate closed-loop control than controlling its position directly and that cursor velocity control was achieved more rapidly than position control.
Neural discharge and local field potential oscillations in primate motor cortex during voluntary movements.
- J. Donoghue, J. Sanes, N. Hatsopoulos, G. Gaál
- Psychology, BiologyJournal of Neurophysiology
- 1998
Widespread coupling of oscillatory signals is consistent with the concept that temporal coding processes operate in motor cortex, but because the relationship between neuronal discharge and the appearance of fast oscillations may be altered by behavioral condition, they must reflect a global process active in conjunction with motor planning or preparatory functions.
Learning-induced LTP in neocortex.
- M. Rioult-Pedotti, D. Friedman, J. Donoghue
- Biology, PsychologyScience
- 20 October 2000
It is demonstrated that synapses in the trained MI were near the ceiling of their modification range, compared with the untrained MI, but the range of synaptic modification was not affected by learning.
Strengthening of horizontal cortical connections following skill learning
- M. Rioult-Pedotti, D. Friedman, Grzegorz Hess, J. Donoghue
- Biology, PsychologyNature Neuroscience
- 1 July 1998
Rats were trained for three or five days in a skilled reaching task with one forelimb, after which slices of motor cortex were examined to determine the effect of training on the strength of horizontal intracortical connections in layer II/III, and this work shows that skill learning is accompanied by changes in thestrength of connections within adult rat primary motor cortex.
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