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Three Mammalian Lipins Act as Phosphatidate Phosphatases with Distinct Tissue Expression Patterns*
We previously identified mutations in the Lpin1 gene, encoding lipin-1, as the underlying cause of lipodystrophy in the fatty liver dystrophy (fld) mutant mouse. Lipin-1 is normally expressed at highExpand
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A Conserved Serine Residue Is Required for the Phosphatidate Phosphatase Activity but Not the Transcriptional Coactivator Functions of Lipin-1 and Lipin-2*
Mammalian lipins (lipin-1, lipin-2, and lipin-3) are Mg2+-dependent phosphatidate phosphatase (PAP) enzymes, which catalyze a key reaction in glycerolipid biosynthesis. Lipin-1 also functions as aExpand
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Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum
The three lipin phosphatidate phosphatase (PAP) enzymes catalyze a step in glycerolipid biosynthesis, the conversion of phosphatidate to diacylglycerol. Lipin-1 is critical for lipid synthesis andExpand
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  • Open Access
Adipose tissue lipin-1 expression is correlated with peroxisome proliferator-activated receptor alpha gene expression and insulin sensitivity in healthy young men.
CONTEXT Lipin-1 functions in adipocyte triglyceride biosynthesis and in the regulation of gene expression, both of which may influence metabolic homeostasis. OBJECTIVE Our objective was toExpand
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Genetic Factors in Type 2 Diabetes
Type 2 diabetes was once referred to as a “geneticist’s nightmare” (1) due to difficulties stemming from the nature of the disease and the strategies available for genetic analysis. Two key geneticExpand
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  • Open Access
Lipin: a determinant of adiposity, insulin sensitivity and energy balance
Lipodystrophy and obesity represent extreme ends of the adiposity spectrum, and both are associated with conditions such as insulin resistance, diabetes and atherosclerosis. This points to a key roleExpand
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Analysis of Gastric Lavage Reported to a Statewide Poison Control System.
BACKGROUND As decontamination trends have evolved, gastric lavage (GL) has become a rare procedure. The current information regarding use, outcomes, and complications of GL could help refineExpand
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