• Publications
  • Influence
The Genome of the African Trypanosome Trypanosoma brucei
African trypanosomes cause human sleeping sickness and livestock trypanosomiasis in sub-Saharan Africa. We present the sequence and analysis of the 11 megabase-sized chromosomes of TrypanosomaExpand
  • 1,503
  • 67
  • PDF
Comparative Genomics of Trypanosomatid Parasitic Protozoa
A comparison of gene content and genome architecture of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major, three related pathogens with different life cycles and disease pathology, revealedExpand
  • 705
  • 39
  • PDF
Detection of Trypanosoma cruzi by DNA amplification using the polymerase chain reaction.
The polymerase chain reaction was used to amplify a 188-base pair (bp) segment of the repetitive 195-bp nuclear DNA sequence of Trypanosoma cruzi that is the most abundant sequence in this organism.Expand
  • 326
  • 24
Trypanosoma brucei FLA1 Is Required for Flagellum Attachment and Cytokinesis*
The single flagellum of the protozoan parasiteTrypanosoma brucei is attached along the length of the cell body by a complex structure that requires the FLA1 protein. We show here that inhibition ofExpand
  • 176
  • 23
Detection of Trypanosoma congolense and Trypanosoma brucei subspecies by DNA amplification using the polymerase chain reaction.
The nuclear DNA of Trypanosoma congolense contains a family of highly conserved 369 base pair (bp) repeats. The sequences of three cloned copies of these repeats were determined. An unrelated familyExpand
  • 265
  • 19
Antigenic variation and the African trypanosome genome.
African trypanosomes are protozoan parasites that reside in the mammalian bloodstream where they constantly confront the immune responses directed against them. They keep one-step-ahead of the immuneExpand
  • 194
  • 17
The major surface protease (MSP or GP63) of Leishmania sp. Biosynthesis, regulation of expression, and function.
Leishmania sp. are digenetic protozoa that cause an estimated 1.5-2 million new cases of leishmaniasis per year worldwide. Among the molecular factors that contribute to Leishmania sp. virulence andExpand
  • 254
  • 13
Nucleotide sequence of the bovine growth hormone chromosomal gene
A library of cloned bovine DNA fragments was constructed and screened for growth hormone sequences. The growth hormone gene was isolated from this library and its nucleotide sequence determined. TheExpand
  • 128
  • 11
Expression and Function of the Trypanosoma brucei Major Surface Protease (GP63) Genes*
The genome of the African trypanosome Trypanosoma brucei (Tb) contains at least three gene families (TbMSP-A, -B, and -C) encoding homologues of the abundant major surface protease (MSP, previouslyExpand
  • 72
  • 11
The African trypanosome genome.
The haploid nuclear genome of the African trypanosome, Trypanosoma brucei, is about 35 Mb and varies in size among different trypanosome isolates by as much as 25%. The nuclear DNA of this diploidExpand
  • 130
  • 9