Share This Author
The Genome of the African Trypanosome Trypanosoma brucei
Comparisons of the cytoskeleton and endocytic trafficking systems of Trypanosoma brucei with those of humans and other eukaryotic organisms reveal major differences.
Comparative Genomics of Trypanosomatid Parasitic Protozoa
No evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont is revealed, and a conserved core proteome of about 6200 genes in large syntenic polycistronic gene clusters is revealed.
The Genome of the African Trypanosome
- J. Donelson
Knowledge of this genomic sequence and its complete set of genes will open many new avenues for identifying better ways to control or eliminate this pathogen and its deadly disease.
Detection of Trypanosoma cruzi by DNA amplification using the polymerase chain reaction
Polymerase chain reaction amplification can be used to evaluate large numbers of samples in a single day and thus should be useful in large-scale studies of the prevalence of T. cruzi in both insect vectors and mammalian hosts.
Trypanosoma brucei FLA1 Is Required for Flagellum Attachment and Cytokinesis*
It is suggested that in procyclic T. brucei, the FLA1 protein has separable functions in flagellar attachment and cytokinesis.
Detection of Trypanosoma congolense and Trypanosoma brucei subspecies by DNA amplification using the polymerase chain reaction
PCR amplification is ideally suited for large-scale studies on the prevalence of African trypanosomes in both mammalian blood and insect vectors as it is about 100 times more sensitive than previous detection methods based on radioactive DNA probes.
Antigenic variation and the African trypanosome genome.
- J. Donelson
- BiologyActa tropica
- 1 March 2003
The major surface protease (MSP or GP63) of Leishmania sp. Biosynthesis, regulation of expression, and function.
Nucleotide sequence of the yeast plasmid
The nucleotide sequence of the yeast DNA plasmid from Saccharomyces cerevisiae strain A364A D5 has been determined and possible functions are suggested, and attributes of an improved vector for cloning foreign DNAs in yeast are discussed.
A monocistronic transcript for a trypanosome variant surface glycoprotein
It is suggested that a new class of trypanosome promoters has been found, whose function is to initiate monocistronic transcription of those VSG genes normally expressed during the metacyclic stage.