Share This Author
Expression of porcine CD163 on monocytes/macrophages correlates with permissiveness to African swine fever infection
Results suggest a role of CD163 in the process of infection of porcine monocytes/macrophages by ASFV, and mAb 2A10 and, in a lower extent, mAb 4E9 were able to inhibit bothASFV infection and viral particle binding to alveolar macrophages.
Immunosuppression in postweaning multisystemic wasting syndrome affected pigs.
The porcine 2A10 antigen is homologous to human CD163 and related to macrophage differentiation.
- C. Sánchez, N. Domenech, J. Vázquez, F. Alonso, A. Ezquerra, J. Domínguez
- BiologyJournal of immunology
- 1 May 1999
2A10+ monocytes could constitute a cell population in a more advanced maturation stage than 2A10- circulating monocytes, and their phenotypic analysis indicates that these cells are more similar to mature macrophages than 2a10- monocytes.
Analysis of cellular immune response in pigs recovered from porcine respiratory and reproductive syndrome infection.
Porcine reproductive and respiratory syndrome (PRRS) virus down-modulates TNF-alpha production in infected macrophages.
Porcine circovirus type 2 (PCV2) viral components immunomodulate recall antigen responses.
Immunohistochemical characterisation of PCV2 associate lesions in lymphoid and non-lymphoid tissues of pigs with natural postweaning multisystemic wasting syndrome (PMWS)
Phenotypic and functional heterogeneity of porcine blood monocytes and its relation with maturation
- S. Chamorro, C. Revilla, B. Álvarez, F. Alonso, A. Ezquerra, J. Domínguez
- 1 January 2005
Swine monocytes constitute a heterogeneous population of cells which can be divided into four subsets based on the expression of SWC3, CD14, CD163 and swine leucocyte antigen (SLA) DR markers, whose capacity for tumour necrosis factor‐α production in response to lipopolysaccharide + interferon‐γ is different.
Porcine monocyte subsets differ in the expression of CCR2 and in their responsiveness to CCL2
The pattern of expression of these chemokine receptors reinforces the similarities of these porcine subsets with their human and mouse counterparts.
African Swine Fever Virus Infection Induces Tumor Necrosis Factor Alpha Production: Implications in Pathogenesis
TNF-α containing supernatants from ASFV-infected cultures induced apoptosis in uninfected lymphocytes; this effect was partially abrogated by preincubation with an anti-T NF-α specific antibody, suggesting a relevant role for TNF- α in the pathogenesis of ASF.