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A unified mixed-model method for association mapping that accounts for multiple levels of relatedness
A unified mixed-model approach to account for multiple levels of relatedness simultaneously as detected by random genetic markers is developed and provides a powerful complement to currently available methods for association mapping. Expand
Structure of linkage disequilibrium and phenotypic associations in the maize genome
Analysis of patterns of local and genome-wide LD in 102 maize inbred lines representing much of the worldwide genetic diversity used in maize breeding suggests that association studies show great promise for identifying the genetic basis of important traits in maize with very high resolution. Expand
A single domestication for maize shown by multilocus microsatellite genotyping
All maize arose from a single domestication in southern Mexico about 9,000 years ago, consistent with a model based on the archaeological record suggesting that maize diversified in the highlands of Mexico before spreading to the lowlands. Expand
Patterns of DNA sequence polymorphism along chromosome 1 of maize (Zea mays ssp. mays L.)
A comparison of genetic diversity between the landrace and inbred samples showed that inbreds retained 77% of the level of diversity of landraces, on average, suggesting that genome-wide surveys for association analyses require SNPs every 100–200 bp. Expand
Dwarf8 polymorphisms associate with variation in flowering time
Historically, association tests have been used extensively in medical genetics, but have had virtually no application in plant genetics. One obstacle to their application is the structuredExpand
The Molecular Genetics of Crop Domestication
The list of genes to date tentatively suggests that diverse plant developmental pathways were the targets of Neolithic "genetic tinkering," and the authors are now closer to understanding how plant development was redirected to meet the needs of a hungry world. Expand
The Effects of Artificial Selection on the Maize Genome
Analysis of single-nucleotide polymorphisms in 774 genes indicates that 2 to 4% of these genes experienced artificial selection, and candidate selected genes with putative function in plant growth are clustered near quantitative trait loci that contribute to phenotypic differences between maize and teosinte. Expand
Genetic structure and diversity among maize inbred lines as inferred from DNA microsatellites.
Comparison of diversity in equivalent samples of inbreds and open-pollinated landraces revealed that maize in breds capture <80% of the alleles in the landrace, suggesting that landraced animals can provide additional genetic diversity for maize breeding. Expand
DNA sequence evidence for the segmental allotetraploid origin of maize.
  • B. Gaut, J. Doebley
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 24 June 1997
The analyses indicate that coalescent times for duplicated sequences fall into two distinct groups, corresponding to roughly 20.5 and 11.4 million years, which strongly discounts the possibility that the maize genome is the product of a genomic allotetraploid event, and also suggests that one of the two ancestral diploids shares a more recent common ancestor with sorghum than it does with the other ancestraldiploid. Expand
Maize association population: a high-resolution platform for quantitative trait locus dissection.
This new association population of 302 lines has the potential to identify QTL with small effects, which will aid in dissecting complex traits and in planning future projects to exploit the rich diversity present in maize. Expand