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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
TLDR
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms. Expand
Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis
TLDR
It is demonstrated that canonical Wnt signalling is necessary for TGF-β-mediated fibrosis and highlight a key role for the interaction of both pathways in the pathogenesis of fibrotic diseases. Expand
Update of EULAR recommendations for the treatment of systemic sclerosis
TLDR
The aim was to update the 2009 European League against Rheumatism recommendations for the treatment of systemic sclerosis, with attention to new therapeutic questions, which resulted in 16 recommendations being developed that address treatment of several SSc-related organ complications. Expand
MicroRNA-29, a key regulator of collagen expression in systemic sclerosis.
TLDR
The expression of miR-29a was strongly down-regulated in SSc fibroblasts and skin sections as compared with the healthy controls and is suggested as a potential therapeutic target by researchers investigating the role of microRNA as posttranscriptional regulators of profibrotic genes in systemic sclerosis. Expand
Genome-Wide Scan Identifies TNIP1, PSORS1C1, and RHOB as Novel Risk Loci for Systemic Sclerosis
TLDR
The genetic signal of association with TNIP1 variants, together with tissular and cellular investigations, suggests that this pathway has a critical role in regulating autoimmunity and SSc pathogenesis. Expand
Uncontrolled Expression of Vascular Endothelial Growth Factor and Its Receptors Leads to Insufficient Skin Angiogenesis in Patients With Systemic Sclerosis
TLDR
It is proposed that chronic and uncontrolled V EGF upregulation that is mediated by an orchestrated expression of cytokines rather than VEGF downregulation is the cause of the disturbed vessel morphology in the skin of SSc patients, which appears to be crucial for therapeutic approaches aiming to improve tissue perfusion. Expand
Platelet-derived serotonin links vascular disease and tissue fibrosis
Blocking 5-HT2B receptor provides a therapeutic target for fibrotic diseases caused by activated platelet release of serotonin during vascular damage.
Neutralisation of Dkk-1 protects from systemic bone loss during inflammation and reduces sclerostin expression
Introduction Inflammation is a major risk factor for systemic bone loss. Proinflammatory cytokines like tumour necrosis factor (TNF) affect bone homeostasis and induce bone loss. It was hypothesisedExpand
Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis.
TLDR
Data show that imatinib mesylate at biologically relevant concentrations has potent antifibrotic effects in vitro and in vivo, without toxic side effects, and is a promising candidate for the treatment of fibrotic diseases such as SSc. Expand
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