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CP-84,657, a potent polyether anticoccidial related to portmicin and produced by Actinomadura sp.
TLDR
CP-84,657 is among the most potent anticoccidal agents known, effectively controlling the Eimeria species that are the major causative agents of chicken coccidiosis at doses of 5 mg/kg or less in feed. Expand
In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity.
TLDR
Dirlotapide demonstrated excellent potency against MTP enzyme in HepG2 cells and canine hepatocytes and showed excellent efficacy when tested in a canine food intake model. Expand
CP-82,009, a potent polyether anticoccidial related to septamycin and produced by Actinomadura sp.
TLDR
CP-82,009 is among the most potent anticoccidial agents known, effectively controlling the Eimeria species that are the major causative agents of chicken coccidiosis at doses of 5 mg/kg or less in feed. Expand
The structure of CP-80,219, a new polyether antibiotic related to dianemycin.
describes the isolation, properties and structure of 1, which is related to dianemycin (2).X) The fermentation of S. hygroscopicus sp. ATCC 53626 and isolation of crude 1-Na as a hexane soluble oilExpand
CP-82,996, a novel diglycoside polyether antibiotic related to monensin and produced byActinomadura sp.
TLDR
CP-82,996 is active against certain Gram-positive bacteria, and is a very potent anticoccidial agent that effectively controlled chicken coccidiosis caused by several Eimeria species at 5–10 ppm in feed, and are 10–20 times more potent than monensin. Expand
Novel erythromycins from a recombinant Saccharopolyspora erythraea strain NRRL 2338 pIG1. I. Fermentation, isolation and biological activity.
TLDR
This paper reports the feeding of short-chained fatty acids to this recombinant strain, and its parent, NRRL 2338, which incorporated exogenously supplied fatty amino acids to produce novel, biologically active, C-13 substituted erythromycins. Expand
Synthesis and structure-activity relationships of thiotetronic acid analogues of thiolactomycin.
3-Acetyl analogues of thiolactomycin, a thiotetronic acid natural product, were synthesized and profiled against livestock pathogens. Some analogues showed improved activity over thiolactomycinExpand
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