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Development of an in vitro cytochrome P450 cocktail inhibition assay for assessing the inhibition risk of drugs of abuse.
The new inhibition cocktail assay was reproducible and applicable for testing the inhibition potential of drugs of abuse as exemplified for 2,5-dimethoxy-4-iodo-amfetamine (DOI).
A microfluidically perfused three dimensional human liver model.
- K. Rennert, Sandra Steinborn, +14 authors Alexander S. Mosig
- Biology, MedicineBiomaterials
- 1 December 2015
It is concluded that the perfused liver organoid shares relevant morphological and functional characteristics with the human liver and represents a new in vitro research tool to study human hepatocellular physiology at the cellular level under conditions close to the physiological situation.
Qualitative studies on the metabolism and the toxicological detection of the fentanyl-derived designer drugs 3-methylfentanyl and isofentanyl in rats using liquid chromatography–linear ion trap–mass…
- M. Meyer, J. Dinger, +4 authors H. Maurer
- Chemistry, MedicineAnalytical and Bioanalytical Chemistry
In urine of rats after the administration of suspected recreational doses, the parent drugs could not be detected, but their common nor metabolite should therefore be the target for urine screening.
In vitro cytochrome P450 inhibition potential of methylenedioxy-derived designer drugs studied with a two-cocktail approach
Results showed that the CYP inhibition by MDD might be clinically relevant, but further studies are needed for final conclusions.
Monocyte-induced recovery of inflammation-associated hepatocellular dysfunction in a biochip-based human liver model
- Marko Gröger, K. Rennert, +10 authors Alexander S. Mosig
- Biology, MedicineScientific reports
- 23 February 2016
The establishment and characterization of a microfluidically supported in vitro organoid model of the human liver sinusoid is reported, which is a valuable tool to investigate sepsis-related liver dysfunction and subsequent immune cell-related tissue repair/remodeling processes.
Corrigendum: Monocyte-induced recovery of inflammation-associated hepatocellular dysfunction in a biochip-based human liver model
This corrects the article DOI: 10.1038/srep21868 to indicate that the author of the paper is a doctor of medicine rather than a scientist, as previously reported.
Development and validation of a liquid-chromatography high-resolution tandem mass spectrometry approach for quantification of nine cytochrome P450 (CYP) model substrate metabolites in an in vitro CYP…
A liquid-chromatography high-resolution tandem mass spectrometry multi-analyte approach was developed and validated and could be used for the development of a CYP inhibition assay for testing most CYPs and a wide range of drugs of abuse.
Preservation of Cell Structure, Metabolism, and Biotransformation Activity of Liver‐On‐Chip Organ Models by Hypothermic Storage
- Marko Gröger, J. Dinger, M. Kiehntopf, F. Peters, U. Rauen, Alexander S. Mosig
- Biology, MedicineAdvanced healthcare materials
This study tested the ability of hypothermic storage of liver-on-chip models to preserve cell viability, tissue morphology, metabolism and biotransformation activity and found a derivative of the tissue preservation solution TiProtec, containing high chloride ion concentrations and deferoxamine, supplemented with polyethylene glycol.
CAAP48, a New Sepsis Biomarker, Induces Hepatic Dysfunction in an in vitro Liver-on-Chip Model
- Nancy Blaurock-Möller, Marko Gröger, +4 authors M. Kiehntopf
- Biology, MedicineFront. Immunol.
- 25 February 2019
Results show that CAAP48 triggers inflammation-related endothelial barrier disruption as well as hepatocellular dysfunction in a liver-on-chip model emulating the pathophysiological conditions of inflammation.
The in vivo and in vitro metabolism and the detectability in urine of 3',4'-methylenedioxy-alpha-pyrrolidinobutyrophenone (MDPBP), a new pyrrolidinophenone-type designer drug, studied by GC-MS and…
In rat urine after a typical user's dose as well as in human urine, mainly the metabolites could be detected using the authors' SUSA by GC-MS and LC-MS(n) .