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The Ehrlich Pathway for Fusel Alcohol Production: a Century of Research on Saccharomyces cerevisiae Metabolism
Current scientific interest in the Ehrlich pathway is supported by increased demands for natural flavor compounds such as isoamyl alcohol and 2-phenylethanol, which can be produced from amino acids in yeast-based bioconversion processes, as well as by the need to control flavor profiles of fermented food products. Expand
The metabolism and molecular physiology of Saccharomyces cerevisiae
LIFE CYCLE AND MORPHOGENESIS J. Richard Dickinson MOTHER CELL-SPECIFIC AGEING Michael Breitenbach, Peter Laun, Gino Heeren, Stefanie Jarolim, and Alena Pichova CARBON METABOLISM Arthur Kruckeberg andExpand
The Catabolism of Amino Acids to Long Chain and Complex Alcohols in Saccharomyces cerevisiae *
The catabolism of phenylalanine to 2-phenylethanol and of tryptophan to tryptophol were studied by13C NMR spectroscopy and gas chromatography-mass spectrometry. Phenylalanine and tryptophan are firstExpand
Pharmaceutical Microbiology
Staphylococcus epidermidis is the leading cause of infections relating to implanted medical devices (Rohde et al 2005). In most natural environments, a biofilm consists of a multispecies bacterialExpand
A 13C Nuclear Magnetic Resonance Investigation of the Metabolism of Leucine to Isoamyl Alcohol in Saccharomyces cerevisiae *
The metabolism of leucine to isoamyl alcohol in yeast was examined by 13C nuclear magnetic resonance spectroscopy and it was found that a pyruvate decarboxylase-like enzyme encoded byYDL080c appears to be the major route of decar boxylation of α-ketoisocaproate to iso amyl alcohol although disruption of this gene reveals that at least one other unidentified decarboxesize can substitute to a minor extent. Expand
An Investigation of the Metabolism of Valine to Isobutyl Alcohol in Saccharomyces cerevisiae *
Analysis of the 13C-labeled products revealed that the pathways of valine catabolism and leucine biosynthesis share a common pool of α-ketoisovalerate, and any single isozyme of pyruvate decarboxylase is sufficient for the formation of isobutyl alcohol from valine. Expand
'Fusel' alcohols induce hyphal-like extensions and pseudohyphal formation in yeasts.
Isoamyl alcohol induced the formation of pseudohyphae in two species of Candida and both hyphal-like extensions and pseudohYPHae in Brettanomyces anomalus, suggesting a close relationship or a common basis to the development of the two morphologies. Expand
Physiological Characterization of the ARO10-Dependent, Broad-Substrate-Specificity 2-Oxo Acid Decarboxylase Activity of Saccharomyces cerevisiae
The results reported here indicate the involvement of posttranscriptional regulation and/or a second protein in the ARO10-dependent, broad-substrate-specificity decarboxylase activity. Expand
Methionine catabolism in Saccharomyces cerevisiae.
The catabolism of methionine to methionol and methanethiol in Saccharomyces cerevisiae was studied using (13)C NMR spectroscopy, GC-MS, enzyme assays and a number of mutants. Methionine is firstExpand
An Investigation of the Metabolism of Isoleucine to Active Amyl Alcohol in Saccharomyces cerevisiae *
The metabolism of isoleucine to active amyl alcohol in yeast was examined by the use of13C nuclear magnetic resonance spectroscopy, combined gas chromatography-mass spectrometry, and a variety of mutants to show that the decarboxylation steps for each α-keto acid in the catabolic pathways of leucine, valine, and isolesucine are accomplished in subtly different ways. Expand