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Cannabinoids reduce levodopa-induced dyskinesia in Parkinson’s disease: A pilot study
The lateral segment of the globus pallidus (GPl) is thought to be overactive in levodopa-induced dyskinesia in PD. Stimulation of cannabinoid receptors in the GPl reduces γ-aminobutyric acid (GABA)Expand
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Disturbance of sequential movements in patients with Parkinson's disease.
The following sequences of two single movements were examined in 10 patients with Parkinson's disease and compared with the performance of 9 normal subjects of similar age. Isometric opposition ofExpand
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Mini-mental state examination in neurological patients.
The Mini-Mental State examination has been found to be a quick and valuable test for simple bedside screening, and for serial assessment of cognitive function in a population of 126 neurologicalExpand
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Motor cortex stimulation in intact man. 2. Multiple descending volleys.
Using an isometric strain gauge, we measured the twitch force produced in the first dorsal interosseous (FDI) muscle by a single anodal shock to the contralateral scalp. At high intensities ofExpand
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Scaling of the size of the first agonist EMG burst during rapid wrist movements in patients with Parkinson's disease.
Rapid wrist flexion movements were studied in a group of 10 patients with Parkinson's disease both on and off their normal drug therapy, and were compared with the same movements made by a group ofExpand
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The Bereitschaftspotential is abnormal in Parkinson's disease.
The average Bereitschaftspotential (BP) preceding a rapid, self-paced voluntary extension movement of the index finger was recorded from 6 scalp locations in 14 patients with Parkinson's disease whoExpand
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Simple and complex movements off and on treatment in patients with Parkinson's disease.
The performance of a 15 degrees elbow flexion and a 30N hand squeeze was studied in nine normal subjects and in five patients with Parkinson's disease. The patients were studied when immobile afterExpand
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Performance of simultaneous movements in patients with Parkinson's disease.
Ten right-handed patients with Parkinson's disease and 9 normal subjects performed five different types of movements as rapidly as possible in their own time: isotonic elbow flexion through an angleExpand
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The Bereitschaftspotential, L-DOPA and Parkinson's disease.
Bereitschaftspotentials (BPs) prior to extension movements of the index finger were studied in normal subjects and in patients with Parkinson's disease. In both, BPs were studied before and afterExpand
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The coexistence of bradykinesia and chorea in Huntington's disease and its implications for theories of basal ganglia control of movement.
Investigation of motor function in a group of 17 patients with Huntington's disease reveals that, in addition to the chorea that many patients exhibit, defects in voluntary motor performance also areExpand
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