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Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain
Visualizing entire neuronal networks for analysis in the intact brain has been impossible up to now. Techniques like computer tomography or magnetic resonance imaging (MRI) do not yield cellularExpand
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Identification of Glyoxalase-I as a Protein Marker in a Mouse Model of Extremes in Trait Anxiety
For >15 generations, CD1 mice have been selectively and bidirectionally bred for either high-anxiety-related behavior (HAB-M) or low-anxiety-related behavior (LAB-M) on the elevated plus-maze.Expand
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Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus.
Degradation of invariant chain (Ii) is a critical step in major histocompatibility complex class II-restricted antigen presentation. Cathepsin L was found to be necessary for Ii degradation inExpand
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Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c.
TNF-alpha-induced apoptosis is thought to involve mediators from acidic vesicles. Cathepsin B (cat B), a lysosomal cysteine protease, has recently been implicated in apoptosis. To determine whetherExpand
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Cathepsin L and Cathepsin B Mediate Reovirus Disassembly in Murine Fibroblast Cells*
After attachment to receptors, reovirus virions are internalized by endocytosis and exposed to acid-dependent proteases that catalyze viral disassembly. Previous studies using the cysteine proteaseExpand
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Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress
Corticotropin-releasing hormone (CRH) is centrally involved in coordinating responses to a variety of stress-associated stimuli. Recent clinical data implicate CRH in the pathophysiology of humanExpand
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Region-specific roles of the corticotropin-releasing factor–urocortin system in stress
Dysregulation of the corticotropin-releasing factor (CRF)–urocortin (UCN) system has been implicated in stress-related psychopathologies such as depression and anxiety. It has been proposed thatExpand
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Forebrain CRF1 Modulates Early-Life Stress-Programmed Cognitive Deficits
Childhood traumatic events hamper the development of the hippocampus and impair declarative memory in susceptible individuals. Persistent elevations of hippocampal corticotropin-releasing factorExpand
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Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer.
Proteolysis in close vicinity of tumor cells is a hallmark of cancer invasion and metastasis. We show here that mouse mammary tumor virus-polyoma middle T antigen (PyMT) transgenic mice deficient forExpand
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Glutamatergic and Dopaminergic Neurons Mediate Anxiogenic and Anxiolytic Effects of CRHR1
An imbalance between CRHR1-controlled anxiogenic glutamatergic and anxiolytic dopaminergic systems might lead to emotional disturbances. The corticotropin-releasing hormone receptor 1 (CRHR1)Expand
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