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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
TLDR
Data indicate that cellular senescence is causally implicated in generating age-related phenotypes and that removal of senescent cells can prevent or delay tissue dysfunction and extend healthspan.
The role of senescent cells in ageing
TLDR
A deeper understanding of the molecular mechanisms underlying the multi-step progression of senescence and the development and function of acute versus chronic senescent cells may lead to new therapeutic strategies for age-related pathologies and extend healthy lifespan.
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice
TLDR
It is shown that mutant mice with low levels of the spindle assembly checkpoint protein BubR1 develop progressive aneuploidy along with a variety of progeroid features, including short lifespan, cachectic dwarfism, lordokyphosis, cataracts, loss of subcutaneous fat and impaired wound healing.
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
TLDR
All IL-12 functions tested were disrupted, including the induction of IFN-γ, mitogenesis, enhancement of natural killer cytolytic function and Thl differentiation.
Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression
TLDR
Forkhead Box M1 (FoxM1), a substrate of Plk1, controls a transcriptional programme that mediates Plk 1-dependent regulation of cell-cycle progression that provides a positive-feedback loop ensuring tight regulation of transcriptional networks essential for orderly mitosis.
Chfr is required for tumor suppression and Aurora A regulation
TLDR
The data suggest that Chfr is a tumor suppressor and ensures chromosomal stability by controlling the expression levels of key mitotic proteins such as Aurora A.
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