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Magnetic resonance imaging of perfusion using spin inversion of arterial water.
- D. S. Williams, J. Detre, J. Leigh, A. Koretsky
- Materials Science, MedicineProceedings of the National Academy of Sciences…
Perfusion images of a freeze-injured rat brain have been obtained, demonstrating the technique's ability to detect regional abnormalities in perfusion.
This technique allows regional perfusion maps to be measured noninvasively, with the resolution of 1H MRI, and should be readily applicable to human studies.
Recommended implementation of arterial spin‐labeled perfusion MRI for clinical applications: A consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia
This review provides a summary statement of recommended implementations of arterial spin labeling (ASL) for clinical applications and describes the major considerations and trade‐offs in implementing an ASL protocol and provides specific recommendations for a standard approach.
The neural basis of the central executive system of working memory
Using functional magnetic resonance imaging to examine brain activation during the concurrent performance of two tasks, which is expected to engage the CES, results support the view that the prefrontal cortex is involved in human working memory.
Reduced Transit-Time Sensitivity in Noninvasive Magnetic Resonance Imaging of Human Cerebral Blood Flow
- D. Alsop, J. Detre
- Materials Science, MedicineJournal of cerebral blood flow and metabolism…
- 1 November 1996
A theoretical framework and experimental methods to more accurately account for transit effects in quantitative human perfusion imaging using endogenous magnetic resonance imaging (MRI) contrast are presented and a novel method for measuring T1, which is fast, insensitive to contamination by cerebrospinal fluid, and compatible with the application of magnetization transfer saturation is presented.
A theoretical and experimental investigation of the tagging efficiency of pseudocontinuous arterial spin labeling
- Wen-Chau Wu, M. Fernández-Seara, J. Detre, F. Wehrli, Jiongjiong Wang
- Physics, MedicineMagnetic resonance in medicine
- 1 November 2007
Arterial spin labeling (ASL) is capable of noninvasively measuring blood flow by magnetically tagging the protons in arterial blood, which has been conventionally achieved using instantaneous (PASL)…
Perfusion functional MRI reveals cerebral blood flow pattern under psychological stress.
- Jiongjiong Wang, H. Rao, +4 authors J. Detre
- MedicineProceedings of the National Academy of Sciences…
- 6 December 2005
The results provide neuroimaging evidence that psychological stress induces negative emotion and vigilance and that the ventral RPFC plays a key role in the central stress response.
Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: A consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia.
The conclusion is that as an optimal default implementation, pseudo-continuous labeling, background suppression, a segmented three-dimensional readout without vascular crushing gradients, and calculation and presentation of both label/control difference images and cerebral blood flow in absolute units using a simplified model are recommended.
The optimal template effect in hippocampus studies of diseased populations
The importance of the template increases when used to study pathology and may be less critical for normal control studies, as explicit geometric optimization of the shape component of the unbiased template positively impacts the study of diseased hippocampi.
Magnetic Resonance Imaging of Glutamate
In a rat brain tumor model with blood-brain barrier disruption, intravenous glutamate injection resulted in a clear elevation of GluCEST and a similar increase in the proton magnetic resonance spectroscopy signal of glutamate, demonstrating the feasibility of using GLUCEST for mapping relative changes in glutamate concentration, as well as pH, in vivo.