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Sickle cell anemia.
People with Sickle Cell Anemia have a deformed hemoglobin in blood called hemoglobin S, which can distort red blood cells into a sickle or crescent shape, which often lead to severe anemia. Expand
Engraftment with peripheral blood stem cells collected by large‐volume leukapheresis for patients with lymphoma
Seven patients with refractory lymphomas underwent marrow reconstitution with peripheral blood stem cells (PBSCs) harvested by large‐volume leukapheresis (LVL) and this group of patients was compared to a control group who received medullary marrow transplants for the same diagnoses under the same protocols during the same period. Expand
Treatment of acute myeloid leukemia in the elderly with low‐dose cytarabine, hydroxyurea, and calcitriol
This regimen has acceptable toxicity and can result in prolonged remissions in elderly, high‐risk patients with AML, and may be related to the synergistic effect of hydroxyurea, cytarabine, and calcitriol. Expand
The management of sickle cell disease in pregnancy.
Management of the patient with sickle cell disease during pregnancy requires intimate knowledge of the patient and her clinical status before pregnancy. The obstetrician must thus seek theExpand
Emphysema, hypoxia and the polycthemic response.
It is a common clinical observation that patients with cyanotic congenital heart disease have hemoglobin and hematocrit levels close to those of normal high-altitude dwellers, whereas many patients with chronic hypoxic lung disease have much lower levels than one might expect from the degree of hypoxia present. Expand
Splenic irradiation in the treatment of patients with chronic myelogenous leukemia or myelofibrosis with myeloid metaplasia : Results of daily and intermittent fractionation with and without
It is concluded that splenic irradiation effectively palliates splenic pain and reverses splenomegaly in the majority of patients with CML and MMM andIntermittent fractionation is more convenient for the patient, appears to be as effective as daily treatment, and may be associated with less hematologic toxicity. Expand
Phase I/II study of cyclophosphamide, carboplatin, and etoposide and autologous hematopoietic stem-cell transplantation with posttransplant interferon alfa-2b for patients with lymphoma and Hodgkin's
CCV is a safe, effective conditioning regimen in patients with NHL or HD and interferon alfa-2b can be safely administered at 2.0 x 10(6) U/m2 three times per week for 6 months and may have a meaningful antitumor effect. Expand
The pH within red blood cells is of fundamental importance as it serves as a governor for both glycolysis and oxygcn dclivery, the former supplying energy and intermediates to maintain erythrocyte function, thc lattcr being crucial to the integrity of the organism. Expand