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Methcathinone and Designer Analogues: Synthesis, Stereochemical Analysis, and Analytical Properties
This paper describes the synthesis, stereochemical analysis, and analy- tical properties of methcathinone and related compounds. Methcathinone represents a new class of designer street drugs that can
GC-MS studies on the six naphthoyl-substituted 1-n-pentyl-indoles: JWH-018 and five regioisomeric equivalents.
The GC-MS properties of the synthetic cannabinoid drug of abuse 3-(1-naphthoyl)-1-pentylindole (JWH-018) and all 5 of its' regioisomeric 1-naphthoyl substituted 1-n-pentylindoles are compared in this
Synthetic cathinones: "a khat and mouse game".
Synthetic cathinone's potent stimulatory effects, coupled with their high abuse potential, and propensity for addiction demands additional pharmacological and toxicological evaluations for these existing and new designer drugs of abuse.
N- and 2-substituted N-(phenylsulfonyl)glycines as inhibitors of rat lens aldose reductase.
Evaluation of the individual enantiomers of series 6 reveals that the S isomers are substantially more active than the corresponding R isomers, and with the exception of the naphthalene analogue 6n, the S stereoisomers of this series display greater inhibitory potencies than the glycines 1.
Synthesis and GC-MS analysis of a series of homologs and regioisomers of 3,4-methylenedioxypyrovalerone (MDPV).
An evaluation of the effects of homologation on gas chromatographic retention showed that addition of a methylene (CH(2)) in the nitrogen-containing ring increases retention more than the equivalent group added to the alkyl side-chain.
Liquid chromatographic determination of the enantiomeric composition of methamphetamine prepared from ephedrine and pseudoephedrine.
. . 282, 609-618. (13) Einarsson, S. J. Chromatogr. 1985, 348, 213-220. (1 4) Mlcrocolumn Separations -Columns, Instrumentation, and Ancillary Techniques; Novotny, M. V.; Ishll, D., Eds.; Elsevier:
Chromatographic and mass spectral methods of identification for the side-chain and ring regioisomers of methylenedioxymethamphetamine.
This study reports the synthesis, chemical properties, spectral characterization, and chromatographic analysis of these 10 unique regioisomers of MDMA, which are synthesized from commercially available precursor chemicals.
Elucidating the neurotoxic effects of MDMA and its analogs.
MDMA and MDMA-analogs can enhance the release of monoamines, alter the monoaminergic neurotransmission, and augment oxidative stress and mitochondrial abnormalities leading to neurotoxicity, which can lead to neurodegeneration.
Liquid chromatographic and mass spectral analysis of N-substituted analogues of 3,4-methylenedioxyamphetamine.
The C1 to C3 N-alkyl, N,N-dimethyl, and N-hydroxy analogues of 3,4-methylenedioxyamphetamine (MDA) are identified by high performance liquid chromatographic (HPLC) and spectrometric techniques. The