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Molecular cloning, expression, and gene localization of a fourth melanocortin receptor.
TLDR
The cloning, expression, and gene localization of a fourth human melanocortin receptor, the melanocortex-4 receptor, is reported, which is expressed primarily in the brain, but its expression is notably absent in the adrenal cortex, melanocytes, and placenta. Expand
Molecular cloning of a novel melanocortin receptor.
TLDR
The molecular cloning and pharmacologic characterization of a third member of this receptor family is reported, which characterizes it as an MSH receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Expand
Molecular cloning of the human histamine H2 receptor.
TLDR
The technique of polymerase chain reaction with oligonucleotide primers based upon the nucleotide sequence of the canine H2 histamine receptor gene, which was recently isolated to clone its human homologue, confirms that it has successfully cloned a novel gene encoding the human H2 Histamine receptor. Expand
Molecular cloning of a gene encoding the histamine H2 receptor.
TLDR
Cimetidine inhibited the binding of the radiolabeled H2 receptor-selective ligand [methyl-3H]tiotidine to the transfected cells in a dose-dependent fashion, but the H1- selective antagonist diphenhydramine did not. Expand
Molecular basis for the interaction of histamine with the histamine H2 receptor.
TLDR
A model for Histamine binding is proposed in which Asp98 is essential for histamine binding and action, Asp186 defines H2 selectivity, and Thr190 is important in establishing the kinetics of histaminebinding, but is not essential for H2Selectivity. Expand
Interaction of dual intracellular signaling pathways activated by the melanocortin-3 receptor.
TLDR
Data indicate that the hMC3R is coupled to both cAMP and inositol phospholipid/Ca(2+)-mediated post-receptor signaling systems and that the latter response is regulated by protein kinase A activity. Expand
Lansoprazole and ranitidine affect the accuracy of the 14C-urea breath test by a pH-dependent mechanism.
TLDR
Intragastric pH recordings revealed that the patients who experienced the most profound gastric acid suppression were those that developed equivocal or false negative UBTs. Expand
Effect of transforming growth factor alpha and interleukin 8 on somatostatin release from canine fundic D cells.
TLDR
TNF-alpha was shown to regulate somatostatin release from cultured D cells in a divergent manner and did not alter basal or secretagogue (cholecystokinin, epinephrine)-mediated somatstatin release. Expand
Distinct receptors for cholecystokinin and gastrin on canine fundic D-cells.
TLDR
These studies delineate the presence of distinct CCK-A andCCK-B/gastrin receptors on canine fundic D-cells and find that the CCk-A receptor selective antagonist L-364,718 dose dependently inhibited CCK'smediated somatostatin release but at the same doses did not alter the effect of gastrin. Expand
Characterization of H2 histamine receptor: linkage to both adenylate cyclase and [Ca2+]i signaling systems.
TLDR
Data from these studies support the notion that a single histamine H2 receptor can be linked to two stimulatory intracellular signaling systems. Expand
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