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Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology: Update 2017.
TLDR
Following the new guidelines for therapeutic drug monitoring in psychiatry holds the potential to improve neuropsychopharmacotherapy, accelerate the recovery of many patients, and reduce health care costs.
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Association Between A2a Receptor Gene Polymorphisms and Caffeine-Induced Anxiety
TLDR
The study shows that an adenosine receptor gene polymorphism that has been associated with Panic Disorder is also associated with anxiogenic responses to an acute dose of caffeine.
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Predictors of elevational biodiversity gradients change from single taxa to the multi-taxa community level
TLDR
This work quantifies cross-taxon consensus in diversity gradients and evaluates predictors of diversity from single taxa to a multi-taxa community level and points to the importance of temperature for diversification and species coexistence in plant and animal communities.
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Cannabinoid receptor 1 (CNR1) gene: Impact on antidepressant treatment response and emotion processing in Major Depression
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International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci
TLDR
A GWAS from the Psychiatric Genomics Consortium is reported in which two risk loci in European ancestry and one locus in African ancestry individuals are identified and it is found that PTSD is genetically correlated with several other psychiatric traits.
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Psychological treatment for panic disorder with agoraphobia: a randomized controlled trial to examine the role of therapist-guided exposure in situ in CBT.
TLDR
Therapist-guided Exposure is more effective for agoraphobic avoidance, overall functioning, and panic attacks in the follow-up period than is CBT without therapist-guided exposure.
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Association of the Anxiogenic and Alerting Effects of Caffeine with ADORA2A and ADORA1 Polymorphisms and Habitual Level of Caffeine Consumption
TLDR
Results showed greater susceptibility to caffeine-induced anxiety, but not lower habitual caffeine intake (indeed coffee intake was higher), in the rs5751876 TT genotype group, and a reduced anxiety response in MH vs NL participants irrespective of genotype.
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Association between ADORA2A and DRD2 Polymorphisms and Caffeine-Induced Anxiety
TLDR
Ass associations between self-reported anxiogenic effects of caffeine and variation in the genes for A2A (ADORA2A) and DRD2 (DRD2) receptors are examined to provide support for an association between an ADORA 2A polymorphism and self- reported anxiety after a moderate dose of caffeine.
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Association of the functional V158M catechol-O-methyl-transferase polymorphism with panic disorder in women.
TLDR
The genotyping of a single nucleotide polymorphism in the coding region of the catechol-O-methyl-transferase (COMT) gene supports a role of the 472G/A (V158M) COMT polymorphism or a nearby locus in the pathogenesis of panic disorder in women.
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TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies
TLDR
Using a mouse model of extremes in trait anxiety, it is shown that anxiety-related behavior was positively correlated with Tmem132d mRNA expression in the anterior cingulate cortex, central to the processing of anxiety/fear-related stimuli, and that in this animal model a T Mem132d SNP is associated with anxiety- related behavior in an F2 panel.
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