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Mater, a maternal effect gene required for early embryonic development in mice
Maternal effect genes produce mRNA or proteins that accumulate in the egg during oogenesis. We show here that Mater, a mouse oocyte protein dependent on the maternal genome, is essential forExpand
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FIGalpha, a germ cell-specific transcription factor required for ovarian follicle formation.
Primordial follicles are formed perinatally in mammalian ovaries and at birth represent the lifetime complement of germ cells. With cyclic periodicity, cohorts enter into a growth phase thatExpand
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A subcortical maternal complex essential for preimplantation mouse embryogenesis.
We have identified a subcortical maternal complex (SCMC) that assembles during oocyte growth and is essential for zygotes to progress beyond the first embryonic cell divisions. At least fourExpand
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FIGalpha, a germ cell specific transcription factor involved in the coordinate expression of the zona pellucida genes.
The mouse zona pellucida is composed of three glycoproteins, ZP1, ZP2 and ZP3, encoded by single-copy genes whose expression is temporally and spatially restricted to oocytes. All three proteins areExpand
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Structural Characterization of Native Mouse Zona Pellucida Proteins Using Mass Spectrometry*
The zona pellucida is an extracellular matrix consisting of three glycoproteins that surrounds mammalian eggs and mediates fertilization. The primary structures of mouse ZP1, ZP2, and ZP3 have beenExpand
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Gamete Recognition in Mice Depends on the Cleavage Status of an Egg’s Zona Pellucida Protein
Getting Gametes Together Despite decades of research, the molecular basis of sperm-egg recognition in mammals remains unresolved. Models in which a glycan ligand in the zona pellucida (ZP)Expand
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Fertility and taxon-specific sperm binding persist after replacement of mouse sperm receptors with human homologs.
The zona pellucida surrounding ovulated mouse eggs contains three glycoproteins, two of which (ZP2 and ZP3) are reported sperm receptors. After fertilization, the zona pellucida is modified adExpand
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Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy
After fertilization, the metalloendoprotease ovastacin is released by cortical granule exocytosis and cleaves the zona pellucida glycoprotein ZP2, an essential step to block sperm binding to anExpand
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Coordinate expression of the three zona pellucida genes during mouse oogenesis.
The mammalian zona pellucida is an extracellular matrix that surrounds growing oocytes, ovulated eggs and early embryos. The mouse zona is composed of three sulfated glycoproteins: ZP1, ZP2 and ZP3.Expand
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Maternal control of early mouse development
The hiatus between oocyte and embryonic gene transcription dictates a role for stored maternal factors in early mammalian development. Encoded by maternal-effect genes, these factors accumulateExpand
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