• Publications
  • Influence
Differential Response Patterns in the Striatum and Orbitofrontal Cortex to Financial Reward in Humans: A Parametric Functional Magnetic Resonance Imaging Study
Responses to monetary reward in humans have been assessed in a number of recent functional imaging studies, and it is clear that the neuronal substrates of financial reinforcement overlap extensivelyExpand
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Neuronal effects of acute citalopram detected by pharmacoMRI
RationaleSerotonin (5-hydroxytryptamine, 5-HT) is implicated in the aetiology and treatment of a variety of psychiatric disorders. A limitation of research has been the necessity to use indirectExpand
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Instrumental responding for rewards is associated with enhanced neuronal response in subcortical reward systems
We show that neuronal responses to financial reward are significantly modulated by the requirement to make a behavioural response, while reward-related response in the orbitofrontal cortex was independent of movement. Expand
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Choice between reinforcer delays versus choice between reinforcer magnitudes: Differential Fos expression in the orbital prefrontal cortex and nucleus accumbens core
Lesions of the orbital prefrontal cortex (OPFC) and the nucleus accumbens core (AcbC) can disrupt performance in inter-temporal choice tasks, possibly by increasing the organism's sensitivity toExpand
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Assessing human 5-HT function in vivo with pharmacoMRI
A number of novel ways of using magnetic resonance imaging (MRI) to visualise the action of drugs on animal and human brain (pharmacoMRI or phMRI) are becoming established tools in translationalExpand
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Effect of disconnecting the orbital prefrontal cortex from the nucleus accumbens core on inter-temporal choice behaviour: A quantitative analysis
Previous experiments showed that destruction of the orbital prefrontal cortex (OPFC) or the nucleus accumbens core (AcbC) in rats altered choice between two delayed food reinforcers. Application of aExpand
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Depression and antisocial personality disorder: two contrasting disorders of 5HT function.
  • J. Deakin
  • Psychology, Medicine
  • Journal of neural transmission. Supplementum
  • 2003
Impaired 5HT functioning has been implicated in two very different psychiatric syndromes: antisocial personality disorder and depression. In both, reduced csf concentration of 5HIAA and bluntedExpand
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Social-economical decision making in current and remitted major depression.
BACKGROUND Prosocial emotions related to self-blame are important in guiding human altruistic decisions. These emotions are elevated in major depressive disorder (MDD), such that MDD has beenExpand
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Brain galanin system genes interact with life stresses in depression-related phenotypes
Significance Early and recent environmental stressors, such as maltreatment in childhood, or stressful life events in adulthood, are important risk factors for depression. Nevertheless, not allExpand
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Effect of quinolinic acid-induced lesions of the subthalamic nucleus on performance on a progressive-ratio schedule of reinforcement: A quantitative analysis
The subthalamic nucleus (STN), a major relay in the indirect striatofugal pathway, plays an important role in extrapyramidal motor control. Recent evidence indicates that it may also be involved inExpand
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