• Publications
  • Influence
Origins and Evolution of Antibiotic Resistance
  • J. Davies, D. Davies
  • Biology, Medicine
  • Microbiology and Molecular Biology Reviews
  • 1 March 1996
TLDR
This review presents the salient aspects of antibiotic resistance development over the past half-century, with the oft-restated conclusion that it is time to act. Expand
The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse
TLDR
Overall, RHA1 appears to have evolved to simultaneously catabolize a diverse range of plant-derived compounds in an O2-rich environment and is established as an important model for studying actinomycete physiology. Expand
A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages
TLDR
The results suggest that cholesterol metabolism is central to M. tuberculosis's unusual ability to survive in macrophages and provide insights into potential targets for novel therapeutics. Expand
Inactivation of antibiotics and the dissemination of resistance genes.
  • J. Davies
  • Biology, Medicine
  • Science
  • 15 April 1994
TLDR
Although bacterial conjugation once was believed to be restricted in host range, it now appears that this mechanism of transfer permits genetic exchange between many different bacterial genera in nature. Expand
The world of subinhibitory antibiotic concentrations.
Although antibiotics have long been known to have multiple effects on bacterial cells at low concentrations, it is only with the advent of genome transcription analyses that these activities haveExpand
Transcriptional modulation of bacterial gene expression by subinhibitory concentrations of antibiotics
TLDR
The studies indicate that the detection of pharmaceutically useful natural product inhibitors could be effectively achieved by measuring activation of transcription at low concentrations in high-throughput assays using appropriate bacterial promoter–reporter constructs. Expand
Novel natural products from soil DNA libraries in a streptomycete host.
As a route to accessing the potential chemical diversity of uncultivable microbes from the soil, combinatorial biosynthetic libraries were constructed by cloning large fragments of DNA isolated fromExpand
Conjugative junctions in RP4-mediated mating of Escherichia coli.
TLDR
It appears that the electron-dense layer between the outer membranes of the conjugating cells is not composed of pilin, as well as in control experiments where the donors lacked conjugative plasmids, and junctions were not observed. Expand
Origins, acquisition and dissemination of antibiotic resistance determinants.
  • J. Davies
  • Biology, Medicine
  • Ciba Foundation symposium
  • 1997
TLDR
This paper examines the proposals that antibiotic resistance genes originated in the bacterial population, either as bona fide resistance genes or genes encoding metabolic functions, and the acquisition of heterologous resistance determinants by different genetic elements and their intergeneric exchange mechanisms. Expand
Transcriptomic Assessment of Isozymes in the Biphenyl Pathway of Rhodococcus sp. Strain RHA1
TLDR
A suite of catabolic enzymes for biphenyl and alkyl-benzenes in RHA1 is delineated, which is larger than previously recognized and which may serve as a model for catabolism in other environmentally important bacteria having large genomes. Expand
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