Filter Results:
- Full text PDF available (13)
Publication Year
1991
2018
- This year (1)
- Last 5 years (15)
- Last 10 years (16)
Publication Type
Co-author
Journals and Conferences
Learn More
- J. Darrell Fontenot, Marc A. Gavin, Alexander Y Rudensky
- Nature Immunology
- 2003
CD4+CD25+ regulatory T cells are essential for the active suppression of autoimmunity. Here we report that the forkhead transcription factor Foxp3 is specifically expressed in CD4+CD25+ regulatory T… (More)
Regulatory T cell-mediated dominant tolerance has been demonstrated to play an important role in the prevention of autoimmunity. Here, we present data arguing that the forkhead transcription factor… (More)
- Adrian O Ozinsky, David M Underhill, +5 authors Alan Aderem
- Proceedings of the National Academy of Sciences…
- 2000
Toll-like receptors (TLRs) have been shown to participate in the recognition of pathogens by the innate immune system, but it is not clear how a restricted family of receptors has the capacity to… (More)
- J. Darrell Fontenot, Jeffrey P. Rasmussen, Marc A. Gavin, Alexander Y Rudensky
- Nature Immunology
- 2005
Regulatory T cells (Treg cells) expressing the forkhead family transcription factor Foxp3 are critical mediators of dominant immune tolerance to self. Most Treg cells constitutively express the… (More)
- Marc A. Gavin, Jeffrey P. Rasmussen, +4 authors Alexander Y Rudensky
- Nature
- 2007
Regulatory CD4+ T cells (Tr cells), the development of which is critically dependent on X-linked transcription factor Foxp3 (forkhead box P3), prevent self-destructive immune responses. Despite its… (More)
- Yuri P. Rubtsov, Jeffrey P. Rasmussen, +9 authors Alexander Y Rudensky
- Immunity
- 2008
The regulatory T (Treg) cells restrain immune responses through suppressor-function elaboration that is dependent upon expression of the transcription factor Foxp3. Despite a critical role for Treg… (More)
- J. Darrell Fontenot, James L. Dooley, Andrew G. Farr, Alexander Y Rudensky
- The Journal of experimental medicine
- 2005
Thymectomy of neonatal mice can result in the development of autoimmune pathology. It has been proposed that thymic output of regulatory T (T reg) cells is delayed during ontogeny and that the… (More)
- J. Darrell Fontenot, Alexander Y Rudensky
- Nature Immunology
- 2005
The random generation of antigen receptors in developing lymphocytes results in a considerable risk of autoimmunity. Regulatory T cells (Treg cells) act in a dominant, trans-acting way to actively… (More)
- Blythe D. Sather, Piper M Treuting, +4 authors Daniel J Campbell
- The Journal of experimental medicine
- 2007
CD4(+)Foxp3(+) regulatory T cells (T reg) are essential for maintaining self-tolerance, but their functional mechanisms and sites of action in vivo are poorly defined. We examined the homing receptor… (More)
- C L Hsieh, Ye Zheng, Yuqiong Liang, J. Darrell Fontenot, Alexander Y Rudensky
- Nature Immunology
- 2006
The relationship between the T cell receptor (TCR) repertoires used by self-reactive transcription factor Foxp3–positive (Foxp3+) CD4+ regulatory T cells (Treg cells) and nonregulatory T cells with… (More)