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Analysis of protein-coding genetic variation in 60,706 humans
TLDR
The aggregation and analysis of high-quality exome (protein-coding region) sequence data for 60,706 individuals of diverse ethnicities generated as part of the Exome Aggregation Consortium (ExAC) provides direct evidence for the presence of widespread mutational recurrence. Expand
UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age
TLDR
The UK Biobank is described, a large population-based prospective study, established to allow investigation of the genetic and non-genetic determinants of the diseases of middle and old age. Expand
Genetic studies of body mass index yield new insights for obesity biology
TLDR
A genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals provide strong support for a role of the central nervous system in obesity susceptibility. Expand
Serious mental disorder in 23 000 prisoners: a systematic review of 62 surveys
TLDR
Although there was substantial heterogeneity among studies (especially for antisocial personality disorder), only a small proportion was explained by differences in prevalence rates between detainees and sentenced inmates. Expand
C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease.
TLDR
The long-term stability of C-reactive protein values was similar to that of both blood pressure and total serum cholesterol, and recommendations regarding its use in predicting the likelihood of coronary heart disease may need to be reviewed. Expand
Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies.
TLDR
The published results from these prospective studies are remarkably consistent for each factor, indicating moderate but highly statistically significant associations with CHD, even though mechanisms that might account for these associations are not clear. Expand
Discovery and Refinement of Loci Associated with Lipid Levels
TLDR
It is found that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Expand
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
TLDR
A meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, finds a long tail of additional common variant loci explaining much of the variation in susceptibility to type 2 diabetes. Expand
Prevalence of serious mental disorder in 7000 refugees resettled in western countries: a systematic review
TLDR
Refugees resettled in western countries could be about ten times more likely to have post-traumatic stress disorder than age-matched general populations in those countries. Expand
Defining the role of common variation in the genomic and biological architecture of adult human height
TLDR
The results indicate a genetic architecture for human height that is characterized by a very large but finite number of causal variants, including mTOR, osteoglycin and binding of hyaluronic acid. Expand
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