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Comparative analysis of IRF and IFN‐alpha expression in human plasmacytoid and monocyte‐derived dendritic cells
TLDR
It is concluded that PDC but not MDDC are uniquely preprogrammed to respond rapidly and effectively to a range of viral pathogens with high levels of IFN‐α production due to the high level of constitutively expressed IRF‐7. Expand
Plasmacytoid dendritic cells and type I IFN: 50 years of convergent history.
TLDR
The signaling pathways in pDC are discussed, their roles in linking innate and adaptive immunity, and their role in infectious disease and autoimmunity are discussed. Expand
Type III IFNs Are Produced by and Stimulate Human Plasmacytoid Dendritic Cells
TLDR
PDC are major producers of IFN-λ1 and -λ2 in response to viral stimulation and also express functional receptors for this cytokine, which can serve as an autocrine signal to strengthen the antiviral response of pDC by increasingIFN-α and IFn-λ production, resulting in prolonged pDC survival. Expand
Human Immunodeficiency Virus Integrates Directly into Naïve Resting CD4+ T Cells but Enters Naïve Cells Less Efficiently than Memory Cells
TLDR
It is found that HIV integrates in the naïve subset of resting CD4+ T cells without prior activation of the cells, supporting the hypothesis that integrated proviral infection of resting T cells can be established without T-cell activation. Expand
Human Immunodeficiency Virus Type 1 Can Establish Latent Infection in Resting CD4+ T Cells in the Absence of Activating Stimuli
TLDR
It is demonstrated that HIV-1 integrates into the genomes of in vitro-inoculated resting CD4+ T cells that have not received activating stimuli and have not entered cell cycle stage G1b. Expand
IFN-lambda1 (IL-29) inhibits GATA3 expression and suppresses Th2 responses in human naive and memory T cells.
TLDR
These data describe unique immunomodulatory effects of IFN-lambda1 and identify novel mechanisms for the reduction of existing Th2 responses and the regulation of new ones, in circulating naive and memory CD4(+) T cells. Expand
Regulation of IFN Regulatory Factor-7 and IFN-α Production by Enveloped Virus and Lipopolysaccharide in Human Plasmacytoid Dendritic Cells1
TLDR
It is demonstrated that both LPS and HSV up-regulate the expression of IRF-7 in PDC, and that this enhancement of IRf-7 is dependent on NF-κB activation, and suggests an activation required for IRF -7 that contributes to IFN-α production in virus-stimulated PDC. Expand
A more precise HIV integration assay designed to detect small differences finds lower levels of integrated DNA in HAART treated patients.
TLDR
A new, sensitive, quantitative assay is developed that allows us to measure integrated DNA in HIV-infected patients and it is found that the use of HAART is associated with reduced levels of integrated DNA. Expand
HIV-1 integrates into resting CD4+ T cells even at low inoculums as demonstrated with an improved assay for HIV-1 integration.
TLDR
It is demonstrated that HIV can integrate into resting CD4(+) T cells in vitro even at low viral inoculum, suggesting there is no threshold number of virions required for HIV to integrate into rested T cells. Expand
Modulation of human β‐defensin‐1 (hBD‐1) in plasmacytoid dendritic cells (PDC), monocytes, and epithelial cells by influenza virus, Herpes simplex virus, and Sendai virus and its possible role in
TLDR
The results suggest that BD‐1 protects mice from influenza pathogenesis with a mechanism other than inhibition of viral replication, and hBD‐1 may play a role in preventing viral replication in immune cells. Expand
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