• Publications
  • Influence
HIV-inhibitory and cytotoxic oligostilbenes from the leaves of Hopea malibato.
Three new oligostilbenes were isolated from the organic extract of the leaves of Hopea malibato and exhibited very modest HIV-inhibitory activity, while compounds 1 and 2 were cytotoxic to the host cells (CEM SS) in the antiviral assay.
Circumdatin G, a new alkaloid from the fungus Aspergillus ochraceus.
The crude extract of the broth of Aspergillus ochraceus was found to inhibit the final stage of polyprotein processing during hepatitis C virus replication, leading to the isolation of the known compound mellein as the active component of the extract.
Cytonic acids A and B: novel tridepside inhibitors of hCMV protease from the endophytic fungus Cytonaema species.
Two novel human cytomegalovirus protease inhibitors, cytonic acids A (1) and B (2), have been isolated from the solid-state fermentation of the endophytic fungi Cytonaema sp. Their structures as
Michellamines D-F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis.
New monomeric (korupensamine E, 6) and dimeric (michellamines D-F, 7-9) naphthylisoquinoline alkaloids have been isolated from exracts of the tropical liana Ancistrocladus korupensis. Structures were
Zerumbone, an HIV-Inhibitory and Cytotoxic Sesquiterpene of Zingiber Aromaticum and Z. Zerumbet
Abstract Zerumbone and 3“,4”-O-diacetylafzelin were isolated from organic extracts of rhizomes of Zingiber aromaticum (Zingiberaceae), and zerumbone and 4-O-acetylafzelin were obtained from organic
20-O-beta-glucopyranosyl camptothecin from mostuea brunonis: A potential camptothecin pro-drug with improved solubility.
The previously unknown 20-O-beta-D-glucopyranosyl camptothecin was essentially inactive in the NCI's in vitro 60-cell line primary antitumor screen, and could be vulnerable to de- glucosidation in vivo, and may merit additional evaluation as a potential prodrug of campthecin that could be more readily formulated than the parent agent.
Triangulynes A-H and trangulynic acid, new cytotxic polyacetylenes from the marine sponge Pellina triangulata.
Nine new polyacetylenes, triangulynes A-H (1-8) and triangulynic acid (9), have been isolated from the marine sponge Pellina triangulata (Oceanapiidae) through cytotoxicity-guided fractionation.
Vasculyne, a new cytotoxic acetylenic alcohol from the marine sponge Cribrochalina vasculum.
A new C43 acetylenic alcohol, vasculyne, was isolated by cytotoxicity-guided fractionation of the Caribbean sponge Cribrochalina vasculum by spectroscopic methods.
Novel naphthoquinones from Conospermum incurvum.
During the reisolation of the trimeric naphthoquinone derivative conocurvone from an extract of the Australian shrub Conospermum incurvum, six monomeric naphTHoquinones were isolated and the structures of the novel 1,4-naphthonones were elucidated by spectral methods.