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Molecular biology.
TLDR
The Ph.D. program in molecular biology is designed to facilitate an interdisciplinary approach to graduate research, utilizing both traditional techniques and the latest advances in biotechnology, including the extraordinary power of recombinant DNA methodology.
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Nuclear Export of MicroRNA Precursors
TLDR
Exposure of Exportin-5 (Exp5) mediates efficient nuclear export of short miRNA precursors (pre-miRNAs) and its depletion by RNA interference results in reduced miRNA levels.
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Accumulation of miR-155 and BIC RNA in human B cell lymphomas.
TLDR
It is found that clinical isolates of several types of B cell lymphomas, including diffuse large B Cell lymphoma (DLBCL), have 10- to 30-fold higher copy numbers of miR-155 than do normal circulating B cells, and the quantities of BIC RNA are elevated in lymphoma cells, but ratios of the amounts of the two RNAs are not constant, suggesting that the level of mi R-155 is controlled by transcription and processing.
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Proofreading and aminoacylation of tRNAs before export from the nucleus.
TLDR
All tRNAs examined can be aminoacylated in nuclei of Xenopus oocytes, thereby providing a possible mechanism for functional proofreading of newly made tRNA, indicating that nuclear aminoacylation promotes efficient export.
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Mechanism of kasugamycin resistance in Escherichia coli.
TLDR
An RNA methylase activity, absent from resistant strains, is shown here to methylate in vitro the 16S RNA of resistant as well as sensitive strains.
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Substrate selectivity of exportin 5 and Dicer in the biogenesis of microRNAs.
TLDR
It is demonstrated that maturation of Xenopus oocytes into eggs leads to a large increase in Dicer activity, suggesting that miRNA biogenesis is subject to developmental control.
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The Matrix Protein of Vesicular Stomatitis Virus Inhibits Nucleocytoplasmic Transport When It Is in the Nucleus and Associated with Nuclear Pore Complexes
TLDR
It is demonstrated that inhibition occurs when M protein is in the nucleus of Xenopus laevis oocytes and that M activity is readily reversed by a monoclonal antibody (αM), and a region of M protein, amino acids 51 to 59, is identified that is required both for inhibition of transport and for efficient recognition by αM.
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The constitutive transport element (CTE) of Mason–Pfizer monkey virus (MPMV) accesses a cellular mRNA export pathway
TLDR
It is shown that an RNA comprised almost entirely of the CTE of Mason–Pfizer monkey virus (CTE RNA) is exported efficiently from Xenopus oocyte nuclei, demonstrating differences in host cell requirements of these two viral mRNA export pathways.
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Deadenylation of maternal mRNAs mediated by miR-427 in Xenopus laevis embryos.
TLDR
It is proposed that microRNA-427, like the orthologous miR-430 of zebrafish, functions to down-regulate expression of maternal mRNAs early in development.
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Coordinated nuclear export of 60S ribosomal subunits and NMD3 in vertebrates
TLDR
It is proposed that NMD3 acts as an adaptor for CRM1–Ran·GTP‐mediated 60S subunit export, by a mechanism that is conserved from vertebrates to yeast.
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