J. D. du Toit

Publications10
h-index8
Citations353
Highly Influential Citations6
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The protective effect of nedocromil sodium and other drugs on airway narrowing provoked by hyperosmolar stimuli: a role for the airway epithelium?
The airways of persons with asthma are sensitive to acute changes in airway osmolarity and to dehydration. In reviewing the literature it is clear that airway narrowing provoked by these stimuli is… Expand
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Characteristics of bronchial hyperresponsiveness in smokers with chronic air-flow limitation.
The characteristics of bronchial hyperresponsiveness (BHR) were studied in 18 smokers with mild chronic air-flow limitation (CAL) by measuring responsiveness to inhaled histamine, methacholine (high… Expand
  • 63
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Acute effect of sodium cromoglycate on airway narrowing induced by 4.5 percent saline aerosol. Outcome before and during treatment with aerosol corticosteroids in patients with asthma.
STUDY OBJECTIVE To investigate the acute effect of sodium cromoglycate on airway responses to 4.5 percent saline aerosol challenge, before and during treatment with inhaled budesonide--a… Expand
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Airway responsiveness in asthma: bronchial challenge with histamine and 4.5% sodium chloride before and after budesonide.
Inhalation of histamine is commonly used to assess the severity of and to monitor treatment of asthma. Histamine causes airways to narrow by acting directly on specific receptors. Hyperosmolar saline… Expand
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Disease investigation into free-ranging Kafue lechwe (Kobus leche kafuensis) on the Kafue Flats in Zambia
infective dose combined with small sample size (if the transmission rate is one-third, as for A0Q/A0Q, there is a 20 per cent chance of observing zero transmissions out of four), or due to resistance… Expand
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Nedocromil sodium inhibits the airway response to hyperosmolar challenge in patients with asthma.
We studied 16 asthmatic subjects sensitive to changes in airway osmolarity to determine whether nedocromil sodium has any effect on airway narrowing caused by hypertonic saline challenges. Nedocromil… Expand
  • 43
Duration of protection by inhaled salmeterol in exercise-induced asthma.
Beta-adrenoceptor agonists such as albuterol are very effective in preventing exercise-induced asthma (EIA) when they are given as an aerosol immediately before exercise. However, their duration of… Expand
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The effect of inhaled frusemide on airway sensitivity to inhaled 4.5% sodium chloride aerosol in asthmatic subjects.
BACKGROUND: Frusemide inhaled by asthmatic subjects before a variety of indirect bronchial challenges inhibits the airway response to these challenges. Since inhalation of hyperosmolar saline is an… Expand
  • 27
The anti-glycolytic action of (S)-alpha-chlorohydrin on epididymal bovine spermatozoa in vitro.
(S)-alpha-Chlorohydrin interferes with glycolysis in bovine spermatozoa whereas the (R)-isomer is ineffective. The action of the (S)-isomer, which involves inhibition of the reaction catalysed by… Expand
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Assessing patients for risk of colorectal cancer in primary care.