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Molecular Cloning of a Non-inactivating Proton-gated Na+ Channel Specific for Sensory Neurons*
TLDR
The cloned and expressed a novel proton-gated Na+ channel subunit that is specific for sensory neurons suggests that it is part of the channel complex responsible for the sustained H+-activated cation current in sensory neurons that is thought to be important for the prolonged perception of pain that accompanies tissue acidosis.
A Modulatory Subunit of Acid Sensing Ion Channels in Brain and Dorsal Root Ganglion Cells*
TLDR
This work has identified MDEG1 as a proton-gated channel with properties different from those of ASIC, and cloned from mouse and rat brain a splice variant form of the channel which differs in the first 236 amino acids, including the first transmembrane region.
Isolation of a Tarantula Toxin Specific for a Class of Proton-gated Na+ Channels*
TLDR
A novel 40-amino acid toxin from tarantula venom is described, which potently blocks a particular subclass of ASIC channels that are highly expressed in both central nervous system neurons and sensory neurons from dorsal root ganglia.
Nonsteroid Anti-Inflammatory Drugs Inhibit Both the Activity and the Inflammation-Induced Expression of Acid-Sensing Ion Channels in Nociceptors
TLDR
Results suggest that the combined capacity to block COXs and inhibit both inflammation-induced expression and activity of ASICs present in nociceptors is an important factor in the action of NSAIDs against pain.
The Acid-sensitive Ionic Channel Subunit ASIC and the Mammalian Degenerin MDEG Form a Heteromultimeric H+-gated Na+ Channel with Novel Properties*
TLDR
This paper shows that ASIC and the mammalian degenerin MDEG, which are colocalized in the same brain regions, can directly associate with each other and can form heteromultimeric assemblies with novel properties.
Modes of Regulation of Shab K+ Channel Activity by the Kv8.1 Subunit*
TLDR
The Kv8.1 subunit expressed at high levels acts as a specific suppressor of the activity of Kv2 and Kv3 channels in Xenopus oocytes and forms hybrid Kv 8.1/Kv2 channels, which have new biophysical properties and more particularly modified properties of the inactivation process as compared with homopolymers of K v2.1 or KV2.2 channels.
H(+)-gated cation channels.
TLDR
The presence of the H(+)-gated Na+ channel throughout the brain suggests that the H+ might play an essential role as a neurotransmitter or neuromodulator, and these two channel proteins are potentially central players in pain perception.
The Pre-transmembrane 1 Domain of Acid-sensing Ion Channels Participates in the Ion Pore*
TLDR
The results suggest that the pre-TM1 region of ASICs participates in the ion pore, and three amino acids in this region appear to be particularly important, because channels mutated at these residues discriminate poorly between Na+ and K+.
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