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Large clonal expansions of CD8+ T cells in acute infectious mononucleosis
Primary infection with Epstein–Barr virus often results in the clinical syndrome of acute infectious mononucleosis (glandular fever). This illness is characterized by a striking lymphocytosis, theExpand
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Oligoclonal Expansions of CD8+ T Cells in Chronic HIV Infection Are Antigen Specific
Acute HIV infection is associated with a vigorous immune response characterized by the proliferation of selected T cell receptor V beta (BV)-expressing CD8+ T cells. These ‘expansions', which areExpand
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Direct visualization of HIV-1-specific cytotoxic T lymphocytes during primary infection
ObjectiveHIV-specific cytotoxic T lymphocytes (CTL) are believed to play an important role in containing viral replication throughout HIV-1 infection. Previous studies have attempted to quantify theExpand
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Testicular feminization in a cat.
Testicular feminization, caused by an inherited defect of the androgen receptor, was diagnosed in a domestic cat. Individuals affected with this syndrome are genetic males that have testes but failExpand
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Research Highlights
Interleukin 6 (IL-6) can signal via the membrane-bound IL-6 receptor (mIL-6R) or can signal in trans using a soluble IL-6 receptor (sIL-6R). In the Journal of Clinical Investigation, Doganci et al.Expand