J. D. Knight
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The myogenic kinome: protein kinases critical to mammalian skeletal myogenesis
Myogenesis is a complex and tightly regulated process, the end result of which is the formation of a multinucleated myofibre with contractile capability. Typically, this process is described as being… Expand
A novel whole-cell lysate kinase assay identifies substrates of the p38 MAPK in differentiating myoblasts
BackgroundThe p38α mitogen-activated protein kinase (MAPK) is a critical mediator of myoblast differentiation, and does so in part through the phosphorylation and regulation of several transcription… Expand
Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity
- Bart-Jan de Kreuk, A. Gingras, J. D. Knight, J. Liu, Anne-Claude Gingras, M. Ginsberg
- Biology, Medicine
- 19 January 2016
Heart of Glass (HEG1), a transmembrane receptor, and Rasip1, an endothelial-specific Rap1-binding protein, are both essential for cardiovascular development. Here we performed a proteomic screen for… Expand
Profiling the kinome: current capabilities and future challenges.
Protein kinases are the second largest human protein family, but in terms of research interest, both basic and applied, they are surely the most popular. Over the past decade, many techniques and… Expand
A proximity biotinylation map of a human cell
Compartmentalization is an essential characteristic of eukaryotic cells, ensuring that cellular processes are partitioned to defined subcellular locations. High throughput microscopy1 and biochemical… Expand