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Naturally-occurring beta-lactamase inhibitors with antibacterial activity.
Identification of 7α-hydroxycephalosporin C as an intermediate in the methoxylation of cephalosporin C by a cell free extract of Streptomyces clavuligerus
Incubation of cephalosporin C with a cell free extract of Streptomyces clavuligerus resulted in the formation of 7α-hydroxycephalosporin C; the same crude enzyme preparation was shown to methylate… Expand
A novel series of milbemycin antibiotics from Streptomyces strain E225. I. Discovery, fermentation and anthelmintic activity.
- J. D. Hood, R. M. Banks, M. Brewer, J. Fish, B. Manger, M. E. Poulton
- Biology, Medicine
- The Journal of antibiotics
- 1 November 1989
A novel series of milbemycin antibiotics were produced by soil isolate, strain E225 which was shown to be a Streptomyces species. The antibiotics displayed anthelmintic activity against… Expand