J. D. Geratz

Publications76
h-index19
Citations1,117
Highly Influential Citations6
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Amelioration of immune complex-mediated glomerulonephritis by synthetic protease inhibitors.
Proteases are involved in the pathogenesis of inflammatory diseases by participating in the activation of mediator systems and by producing proteolytic tissue injury. Homeostatic control of… Expand
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Regulation of pancreatic enzyme levels by trypsin inhibitors.
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Angiosarcoma of the uterus: a light microscopic, immunohistochemical, and ultrastructural study.
A 71-year-old woman who presented with severe vaginal bleeding was found to have a uterine angiosarcoma after total abdominal hysterectomy and bilateral salpingo-oophorectomy. The diagnosis was… Expand
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Enhancement of respiratory syncytial virus-induced cytopathology by trypsin, thrombin, and plasmin.
A series of proteases of diverse substrate specificity were tested for their effect on respiratory syncytial virus-induced cytopathology. Three of the enzymes, thrombin, plasmin, and trypsin, were… Expand
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Additions and Corrections - Diamidino-α,ι-diphenoxyalkanes. Structure-Activity Relationships for the Inhibition of Thrombin, Pancreatic Kallikrein, and Trypsin.
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Analogues of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) in the treatment of experimental Pneumocystis carinii pneumonia.
A series of 33 analogues of the anti-Pneumocystis carinii drug 1,5-bis(4-amidinophenoxy)pentane (pentamidine) was synthesized for screening against a rat model of P. carinii pneumonia (PCP).… Expand
  • 120
Novel pentamidine analogs in the treatment of experimental Pneumocystis carinii pneumonia.
We have recently demonstrated that substitution of imidazoline moieties for the amidine groups of pentamidine produces a molecule that is effective against rat Pneumocystis carinii pneumonia and that… Expand
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Diarylamidine derivatives with one or both of the aryl moieties consisting of an indole or indole-like ring. Inhibitors of arginine-specific esteroproteases.
A series of 62 diarylamidine derivatives was evaluated for their antiproteolytic activity. In all but two of the compounds one or both of the amidino-substituted aryl moieties was either an indole or… Expand
  • 111
Development of Pentamidine Analogues as New Agents for the Treatment of Pneumocystis carinii Pneumonia a
The synthesis and antiprotozoal activity of l,S-di(4-amidinophenoxy)pentane, pentamidine, was first reported in the late 1930s.' During the early 1940s hundreds of pentamidine analogues were… Expand
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Aromatic Tris-amidines. A new class of highly active inhibitors of trypsin-like proteases.
A number of novel aromatic Tris-amidines have been synthesized and investigated for their antiproteolytic property. The basic structure of the compounds is that of mesitylene where each of the methyl… Expand
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