Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility.
- M. Valdearcos, J. D. Douglass, S. Koliwad
- Biology, MedicineCell Metabolism
- 5 July 2017
Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility.
- M. Valdearcos, J. D. Douglass, S. Koliwad
- BiologyCell Metabolism
- 1 June 2018
Astrocyte IKKβ/NF-κB signaling is required for diet-induced obesity and hypothalamic inflammation
- J. D. Douglass, M. Dorfman, R. Fasnacht, L. Shaffer, J. Thaler
- Biology, MedicineMolecular Metabolism
- 28 January 2017
Global deletion of MGL in mice delays lipid absorption and alters energy homeostasis and diet-induced obesity
- J. D. Douglass, Y. Zhou, J. Storch
- Biology, ChemistryJournal of Lipid Research
- 1 June 2015
The results indicate that global MGL deletion leads to systemic changes that produce a leaner phenotype and an improved serum metabolic profile, suggesting delayed lipid absorption.
Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice
- M. Dorfman, Jordan E. Krull, J. Thaler
- BiologyNature Communications
- 22 February 2017
Sex-specific regulation of hypothalamic microglial activation through CX3CR1 signalling is revealed, providing a potential mechanism for differential susceptibility to diet-induced obesity.
Over-Expression of Monoacylglycerol Lipase (MGL) in Small Intestine Alters Endocannabinoid Levels and Whole Body Energy Balance, Resulting in Obesity
- Suhyoun Chon, J. D. Douglass, J. Storch
- Biology, MedicinePLoS ONE
- 28 August 2012
A role for intestinal MGL, and intestinal 2-AG and perhaps other MG species, in whole body energy balance via regulation of food intake as well as metabolic rate is suggested.
Glia: silent partners in energy homeostasis and obesity pathogenesis
- J. D. Douglass, M. Dorfman, J. Thaler
- BiologyDiabetologia
- 1 February 2017
This work has revealed the involvement of a wide variety of glial cell types in the modulation of neuronal activity, regulation of hormone and nutrient availability, and participation in the physiological regulation of feeding behaviour.
Alterations in the intestinal assimilation of oxidized PUFAs are ameliorated by a polyphenol-rich grape seed extract in an in vitro model and Caco-2 cells.
- R. Maestre, J. D. Douglass, S. Kodukula, I. Medina, J. Storch
- BiologyJournal of NutriLife
- 1 March 2013
Adding polyphenols during active digestion can limit the development of PUFA oxidation products in the small intestine lumen and thereby promote intestinal uptake of the beneficial, unoxidized, (n-3) PUFAs.
Intestinal Mucosal Triacylglycerol Accumulation Secondary to Decreased Lipid Secretion in Obese and High Fat Fed Mice
- J. D. Douglass, Nashmia Malik, J. Storch
- BiologyFront. Physio.
- 24 February 2012
Analysis of intestinal lipid extracts from fed and fasted animals demonstrated that the mucosa accumulates excess lipid during obesity, and changes in the expression of lipid metabolic and transport genes, as well as reduced secretion of dietary lipid from the mucosal cells into the circulation, may contribute to the TG accumulation in intestinal mucosa.
Erratum: Global deletion of MGL in mice delays lipid absorption and alters energy homeostasis and diet-induced obesity
- J. D. Douglass, Y. Zhou, J. Storch
- BiologyJournal of Lipid Research
- 27 February 2019
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