• Publications
  • Influence
Interactions of morphine and isoflurane in horses.
The results do not support routine clinical use of MOR administered IV at dosages of 0.25 or 2.0 mg/kg as an adjuvant to anesthesia in horses administered ISO.
Some aspects of clinical pharmacokinetics in veterinary medicine II
The concept of the two compartment and three compartment models for drug disposition are introduced and developed to demonstrate the mathematical models which may be derived to describe the kinetics of drug distribution and elimination.
Antimicrobial therapy and bacterial resistance: a pilot survey
Evidence that R factor evolved before the advent of the antibiotic era is presented, and this interesting finding does not diminish the contribution of frequent antibiotic usage to the development of bacterial resistance.
Plasma and synovial fluid concentrations of gentamicin in horses after intra-articular administration of buffered and unbuffered gentamicin.
Mean synovial fluid concentration did not differ significantly between groups after IA administration of gentamicin in any combination at postinjection hours 8, 12, and 24, but remained significantly (P less than 0.05) greater than that at the same times after IV administration.
Tylosin antimicrobial activity and pharmacokinetics in cows.
Influence of Inhaled Anesthetics on the Pharmacokinetics and Pharmacodynamics of Morphine
During conditions of a similar constant level of anesthesia (inhaled anesthetic plus morphine) there is little or no difference in disposition kinetics of morphine; and there is no anesthetic‐related difference in the magnitude of morphine‐induced respiratory depression during inhaled anesthesia, a depression that can be abolished by noxious stimulation and naloxone.
Pharmacokinetics and dosage of aspirin in cattle.
Sodium salicylate was given intravenously to clinically normal cows and aspirin (acetylsalicylic acid) was given orally to arthritic and clinically normal cattle, which was considered to be therapeutically effective.
Adverse effects of imidocarb dipropionate (Imizol®) in a dog
Autopsy findings showed marked pulmonary congestion and oedema, Kidneys were grossly enlarged and markedly congested with extensive haemorrhage in the cortex and medulla, and marked tubulonephrosis was also exhibited microscopically.
Morphine-isoflurane interaction in dogs, swine and rhesus monkeys.
PaCO2 rose at constant MAC with morphine to 55-60 mmHg, but did not fall over the next several hours despite the decline of plasma morphine concentration, and the resulting needed rise in isoflurane concentration to keep the anaesthesia depth at 1 MAC.
The pharmacokinetics of some aminoglycoside antibiotics in the horse.
The disposition kinetics and bioavailability of streptomycin, kanamycin and neomycin were determined following their administration as parenteral preparations to horses and the only pharmacokinetic difference between these aminoglycosides that is of clinical importance lies in the rate of their elimination.